精神分裂症患者和一级亲属全血23种微量元素含量的测定与分析  

Blood concentration of 23 trace elements in schizophrenic patients and their first degree relatives

作　　者：王丽[1,2] 周俊清 郭世平[1,2] 孙艳杰 张丽华 

机构地区：[1]白求恩医科大学预防医学院 [2]长春市精神病医院

出　　处：《中国公共卫生》1999年第8期723-724,共2页Chinese Journal of Public Health

摘　　要：采用等离子体发光法测定６６例精神分裂症病人、２４例精神分裂症病人的健康一级亲属和５０例正常对照３组人群全血２３种微量元素含量。结果显示：精神分裂症病人铝（Ａｌ）、铜（Ｃｕ）、锌（Ｚｎ）、钡（Ｂａ）和铬（Ｃｒ）的含量显著低于对照组（Ｐ＜００５），铁（Ｆｅ）、镁（Ｍｇ）和硼（Ｂ）含量显著高于对照组（Ｐ＜００５），一级亲属铁（Ｆｅ）、镁（Ｍｇ）和硼（Ｂ）含量显著高于对照组（Ｐ＜００５）；同时铜（Ｃｕ）、钙（Ｃａ）和钡（Ｂａ）低于对照组（Ｐ＜００５）；精神分裂症病人与其一级亲属组相比无明显差异（Ｐ＞００５）。提示精神分裂症病人存在微量元素代谢异常，这种异常可能是精神分裂症病理过程的表现，同时遗传因素对精神分裂症的发生有一定作用。The blood concentration of 23 trace elements in 66 schizophrenic patients,24 their first degree relatives,and 50 health volunteers were detected.The results demonstrated that the levels of Al,Cu,Zn,Ba,Cr in schizophrenic patients were much lower than those in health volunteers(P<0 05),while the levels of Fe,Mg,B were much higher than those in health volunteers(P<0 05).The levels of Fe,Mg,B in first degree relatives were higher than those of health volunteers(P<0 05),while the levels of Cu,Ca,Ba were lower than those of health volunteers(P< 05).There was no significantly difference between schizophrenic patients and their first degree relatives(P>0 05).The results mentioned above suggested that the abnonmal metabolism of trace elements might be related with schizophrenia,and the genetic factors might play an important role in schizophrenia.

关 键 词：精神分裂症 微量元素 测定 亲属 

分 类 号：R749.3[医药卫生—神经病学与精神病学]