侵袭性血管粘液瘤——附4例临床病理分析  

Aggressive angiomyxoma : a clinicopathologic study of 4 cases

作　　者：廖晓耘[1] 李荣[1] 回允中[1] 

机构地区：[1]北京医科大学人民医院病理科

出　　处：《北京医科大学学报》1999年第4期376-378,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：分析侵袭性血管粘液瘤的临床和病理学特点。方法：对１９８８年３月～１９９８年６月我院收治的４例侵袭性血管粘液瘤患者的临床资料进行回顾性分析，并对其病理切片行免疫组化染色。结果：４例均为女性，年龄３９～５０岁；３例发生在外阴，１例在盆腔底部。肿瘤最大径４～１５ｃｍ。免疫组化染色肿瘤细胞阳性反应分别为ｖｉｍｅｎｔｉｎ（４／４）、ｄｅｓｍｉｎ（４／４）、ａｃｔｉｎ（１／４）、ＳＭＡ（１／４）、ＣＤ３４（３／４），Ｓ１００蛋白为阴性；雌激素受体、孕激素受体全部呈强阳性表达。随访４例均无复发和转移。结论：侵袭性血管粘液瘤是一种少见的特征性的间叶性肿瘤，主要累及成年女性的会阴和盆腔，肿瘤呈浸润性生长，但不发生转移。肿瘤具有鲜明的病理组织学特点，免疫组化显示肿瘤细胞可能为纤维母细胞／肌纤维母细胞来源，在其生长过程中激素可能起一定的作用。Objective: To investigate the clinical and pathologic features of aggressive angiomyxoma(AA). Methods: 4 cases histologically confirmed as AA and treated in our hospital from Mar.1988 to Jun.1998 were retrospectively studied. In the meanwhile, the immunohistochemistry was utilized to further characterize the neoplasms. Results: All the 4 patients were females, aged between39 and 50 years; the soft tissues of vulva in 3 patients and pelvis floor in 1 patient were involved. The immunoreactivities of the neoplastic cells were vimentin (4/4), desmin (4/4), actin (1/4), SMA (1/4), CD34 (3/4), and S 100 protein negative; All of the tumors were strongly positive for estrogen and progesterone receptor. Follow up studies ranged from 2～124 months, and no patient developed recurrence and metastases. Conclusions: Aggressive angiomyxoma is a rare, distinctive mensenchymal neoplasm characterized by locally infiltrative growth and a lack of metastases. The major sites of involvement are vulva and pelvis floor. The immunohistochemistry of the neoplastic cells exhibits some of fibroblastic and myofibroblastic features, and they appear to be hormonally influenced.

关 键 词：血管肿瘤 血管粘液瘤 病理分析 

分 类 号：R732.202[医药卫生—肿瘤]