2,5-呋喃二甲酸的合成  

Synthesis of Furan-2,5-dicarboxylic Acid

作　　者：刘浪[1] 杨顺利 李鸿波[1] 陈凯[1] 吴毅[1] 马昌鹏[1] 张永岗[1] 杨俊卿[1] 

机构地区：[1]西南科技大学材料科学与工程学院,四川绵阳621010 [2]凯新化学有限公司,四川绵阳621000

出　　处：《精细化工》2011年第4期410-412,共3页Fine Chemicals

基　　金：四川省科技厅项目(2006J13-143);西南科技大学引进人才项目(053115)~~

摘　　要：以糠酸为原料,经过酯化、氯甲基化、水解、氧化得到2,5-呋喃二甲酸,并对各步反应中的工艺参数进行了优化。优化结果:酯化反应时间为10 h,氯甲基化反应温度为35～40℃,水解反应原料摩尔比为n(氢氧化钠)∶n(5-氯甲基-2-呋喃甲酸甲酯)=2.1∶1,氧化反应体系pH=7～8,反应总收率47.5%。按该工艺顺利完成了3次20 L扩试反应,平均收率可达47.3%,产品HPLC纯度大于99.4%。Furan-2,5-dicarboxylic acid was synthesized from furoic acid through esterification,chloromethylation,hydration and oxidation,and the important process parameters in each step were also optimized.The optimal reaction conditions were obtained as follows：the time of esterification was 10 hours,the temperature of chloromethylation was 35～40 ℃ n（sodium hydroxide）∶n（methyl 5-chloromethyl-furan-2-carboxylate）=2.1∶1 in hydration,pH=7～8 in oxidation,the total yield was 47.5%.Under the optimized conditions,the synthetic method of furan-2,5-dicarboxylic acid was successfully carried out three times in 20 L reactor and the average yield could reach 47.3%,and the purity of the product was over 99.4%.

关 键 词：糠酸 2 5-呋喃二甲酸 5-氯甲基-2-呋喃甲酸甲酯 精细化工中间体 

分 类 号：TQ463.53[化学工程—制药化工]