大鼠抑郁症模型的建立与评价  

Establishment and Evaluation of the Animal Model of Depressed Rats

作　　者：汤球[1] 刘志学[1] 崔淑芳[1] 蔡丽萍[1] 

机构地区：[1]第二军医大学实验动物中心,上海200433

出　　处：《实验动物科学》2011年第1期6-9,共4页Laboratory Animal Science

摘　　要：目的建立大鼠抑郁症模型并进行评价。方法将40只大鼠随机分为空白对照组、模型组,采用慢性、中等和不可预知应激刺激建立抑郁症模型,观查大鼠行为学指标:大鼠敞箱试验、糖水消耗试验、食物消耗量、去甲肾上腺素(NE)、5-羟色胺(5-HT)和皮质醇(CORT)水平。结果与正常组比较,模型组的水平得分垂直得分、糖水消耗、体重、进食量、NE、5-HT、CORT较空白组有明显差异(P<0.05或P<0.01)。结论采用慢性、中等和不可预知应激刺激建立的抑郁症模型符合抑郁症的特征,可作为抑郁症实验模型。Objective To establish the animal model of depressed rats and evaluate the related parameters.Methods A total of 40 adult SD rats were randomly divided into control group（n = 20） and model group（n = 20）.Using the chronic unpredictable mild stress to establish the animal model of depressed rats.The behavior of rats was tested at each weekend.The behaviors of rats were evaluated by open-field test,and the consumption of saccharose,body weight,and the content of NE、5-HT、CORT were observed too.Results There were differences in crossing and rearing score in open-field test,the consumption of saccharose,body weight,intake,NE,5-HT,CORT between model groups and blank control groups（P〈0.05orP〈0.01）.Conclusion Using the chronic unpredictable mild stress the animal model of depressed rats was established which accorded with the requested characteristics of depression,and could be regarded as experimental model of depression.

关 键 词：抑郁症 动物模型 评价 

分 类 号：R749[医药卫生—神经病学与精神病学]