血清酸性同工铁蛋白对原发性肝癌的诊断意义  

The Diagnostic Significance of Serum Acidic Isoferrintin in PatientsWith Primary Hepatocellular Carcinoma

作　　者：邹岚[1] 郝德治[2] 蔡桂英[3] 魏玲[3] 

机构地区：[1]第三军医大学附属西南医院肿瘤科 [2]华西医科大学附一院肿瘤科,610041 [3]华西医科大学基础生化教研室

出　　处：《重庆医学》1999年第5期343-344,共2页Chongqing medicine

摘　　要：目的：研究血清酸性铁蛋白对原发性肝癌的诊断意义。方法：采用ＥＬＩＳＡ（双抗体夹心法）测定４８例原发性肝细胞癌（ＨＣＣ），３０例肝炎，２８例肝硬化及３３例正常人血清酸性同工铁蛋白（ＳＡＩＦ）水平。结果：ＨＣＣ组与各组比较，均有显著差异。以ＳＡＩＦ＼２５０ｕｇ／Ｌ为临界值 ＳＡＩＦ对 ＨＣＣ诊断的灵敏度为 ８５． ４６％，特异度为 ８６． ８１％。并且 ＳＡＩＦ与 ＡＦＰ无相关性， ＡＦＰ阳性与 ＡＦＰ阴性的患者中， ＳＡＩＦ灵敏度分别为 ９０． ９２％和 ７３． ３３％，两者差异无统计学意义。将 ＳＡＩＦ与 ＡＦＰ联合检测，可将 ＨＣＣ检出率提高到 ９１． ６％，而特异度为 ９６ ７％。 ＳＡＩＦ与肝癌大小无关。objective:To evaluate the diagnostic significance of serum acidic isoferrintin in patients with primary hepato cellular carcinoma. Methods: The leveis of serum acidic isoferritin (SAIF) in 48 cases of ptimary hepatocellular carcinoma (HCC), 30 cases of hepatitis, 28 cases of liver cirrihosis, as well as 33 healthy subjects were measured with ELISA (double -- determinant). Results: With the cut -- off point being 250ug/L, the sensitivity and specificity to HCC cases were 85. 46% and 86. 81 % respectively. SAIF was not related to AFP in HCC cases. In AFP(+) and AFP (-) patients, the sensitivity of SAIF had no significant difference (90. 92%, 73.33%;P>0.05). The parallel test of AFP and SAIF can improve the dignosis of HCC. The valuses of SAIF were not related to the volumes of the tumors and the clinical stages. SAIF is a useful serum marker for the diagnosis of HCC.

关 键 词：血清 酸性同工铁蛋白 原发性 肝癌 诊断 ELISA 

分 类 号：R735.704[医药卫生—肿瘤]