烹调油烟所致大鼠肺部病变的时相分析  

Dynamic Analysis about Changes of Histormorphological of Lung Tissues in Rats Exposed to COF

作　　者：让蔚清[1] 周少琴 苏琦[2] 李东阳 

机构地区：[1]湖南衡阳医学院卫生学教研室,421001 [2]湖南衡阳医学院肿瘤研究所

出　　处：《中国公共卫生》1999年第9期793-794,共2页Chinese Journal of Public Health

基　　金：湖南省教委资助项目;衡阳医学院硕士研究生课题

摘　　要：利用吸入烹调油烟（ 浓度为４３ ±４ｍｇ／ ｍ３） 持续染毒２０ 、４０ 、６０ 天制备动物模型，通过常规 Ｈ Ｅ 染色，光学显微镜观察肺部病理形态改变。结果表明， Ｃ Ｏ Ｆ 染毒组肺组织病理形态改变以炎症改变为主，尚有肺泡上皮腺样化生，不典型腺样增生病变形成。以第三时相病变更为明显。阴性对照组有轻度间质性肺炎及轻度的上皮增生。 Ｂ（ａ） Ｐ 组肺组织炎症病变少，以鳞状上皮化生较多见。Objective:Spranque dawley (SD) rats were exposed to subacute dose cooking oil fumes(COF) in order to observe pathological changes of lung tissues. Mathods:Rats of test group and negative group inhaled COF (43±4mg/m 3×30min/d×20,40,60d) and hot air (30min/d×20,40,60d) respectively,while positive control group was droped B(a)P into lung from trachea(12mg/kg/5d×20,40,60d).Pathological changes of lung tissues in rats were observed by microscope. Results:in the study, the following feautures were noticed:The main pathological changes of test group is inflammation,Alueolar epithelial hyperplasia are also found,local mild epithelial hyperplasia and mesenchymal pneumonia are found in negative control group. The main pathological changes of positive control group is squamous epithelial metaplasia in lobar and aegmental bronchia. Conclution , COF may induce adenic metaplasia and precancerous lesions.

关 键 词：烹调油烟 病理改变 时相分析 肺病变 

分 类 号：R563.02[医药卫生—呼吸系统] R126.8[医药卫生—内科学]