复方通络胶囊预处理大脑中动脉缺血再灌注大鼠后血浆vWFTM含量和MMP-2 mRNA表达的变化  

Change of vWF TM Content and MMP-2 mRNA Expression in Plasma of Middle Cerebral Artery Ischemia-reperfusion Rats Pretreated by Fufang Tongluo Capsule

作　　者：王敬卿[1] 肖婧[2] 张绒[2] 

机构地区：[1]南京市中医院,江苏南京210001 [2]南京中医药大学,江苏南京210046

出　　处：《辽宁中医药大学学报》2011年第4期251-252,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：南京市卫生局医学课题(YKK0456)

摘　　要：目的:观察复方通络胶囊对大脑中动脉缺血再灌注(MCAO)大鼠的预防性脑保护作用。方法:采用MCAO大鼠模型,造模前大鼠灌胃给药1周,以血浆血管性血友病因子(vWF)、血栓调节蛋白(TM)含量和基质金属蛋白酶-2(MMP-2)mRNA的表达为指标,观察复方通络胶囊对MCAO大鼠的作用机制。结果:复方通络胶囊能明显降低模型动物血浆vWF、TM含量,与模型组比较差异显著(P<0.05),并且能抑制MMP-2 mRNA的表达。结论:复方通络胶囊能够降低模型动物血浆vWF、TM含量,抑制MMP-2 mRNA的表达,对MCAO大鼠有预防性脑保护作用。Objective：To observe the preventively protective effect of Fufang Tongluo capsule on middle cerebral artery ischemia-reperfusion（MCAO）rat＇s brain.Methods：The MCAO rats are fed with Fufang Tongluo capsule by gavages before operated.Then we choose von Willebrand factor（vWF）,thrombomodulin（TM）content and matrix metalloproteinase-2（MMP-2）mRNA expression in the plasma as indicators to observe the mechanism of Fufang Tongluo capsule effect on the MCAO rats.Results：Fufang Tongluo capsule can significantly reduce plasma vWF,TM content with model rats,compared with the model group（P0.05）,and inhibit MMP-2 mRNA expression.Conclusion：Fufang Tongluo capsule can reduce plasma vWF,TM content;inhibit expression of MMP-2 mRNA,which has preventive cerebral protection to MCAO rats.

关 键 词：复方通络胶囊预处理 大脑中动脉缺血再灌注 VWF TM MMP-2 mRNA复方通络胶囊预处理 大脑中动脉缺血再灌注 VWF TM MMP-2 MRNA 

分 类 号：R-332[医药卫生]