山东汉族梅毒患者与HLA-A、B等位基因的相关性研究  

Association of HLA-A and -B alleles with syphilis in Shandong Han population

作　　者：蒋红伟[1] 田洪青[1] 李中伟[1] 李娜[1] 赵毅[1] 刘殿昌[1] 刘兵[1] 初同胜[1] 刘红[1] 侯建玲[1] 郑荣涛[1] 

机构地区：[1]山东省皮肤病性病防治研究所,济南250022

出　　处：《中华皮肤科杂志》2011年第2期124-126,共3页Chinese Journal of Dermatology

基　　金：国家＂十一五＂攻关项目（2006BA702B01）

摘　　要：目的 探讨山东汉族梅毒患者与HLA-A、B等位基因的相关性.方法 采用PCR-序列特异性寡核苷酸探针杂交（PCR-SSOP）方法对205例山东汉族梅毒患者与5844例山东汉族正常对照的HLA-A、B等位基因表现频率进行检测.结果 梅毒患者组HLA-A＊02,B＊15、40等位基因频率高于对照组（P值均＜0.01;Pc值均＜0.05）,HLA-A＊26等位基因频率低于对照组（P=0.003;Pc=0.039）,HLA-B＊15、40等位基因频率在显性梅毒组高于对照组（P值均＜0.01;Pc值均＜0.05）,HLA-A＊02、11、29,B＊15、40等位基因频率在隐性梅毒组高于对照组（P值均＜0.01;Pc值均＜0.05）,HLA-A＊30、33等位基因频率在隐性梅毒组低于对照组（P值、Pc值分别为0.002、0.026;0.001、0.013）,HLA-A＊30等位基因频率在显性梅毒组高于隐性梅毒组（P=0.001;Pc=0.013）.结论 HLA-A＊02,B＊15、40等位基因可能与山东汉族梅毒相关,HLA-A＊30可能与山东汉族显性梅毒相关,HLA-A＊02、11、29可能与山东汉族隐性梅毒相关.Objective To investigate the association of HLA-A and -B alleles with syphilis in 5handong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5944 normal human controls by PCR-sequence specific oligouueleotide probe （PCR-SSOP） method. Results The patients with syphilis showed a higher frequency of HLA-A＊02, B＊15, B＊40 alleles （all P 〈 0.01, Pc 〈 0.05） and a lower frequency of HLA-A＊26 allele （P = 0.003, Pe = 0.039） than the normal human controls did. There was an increased frequency of HLA-B＊15 and B＊40 alleles in patients with symptomatic syphilis （both P 〈 0.01, Pc 〈 0.05 ）, as well as an elevated frequency of HLA-A＊02, 11, 29, B＊ 15 and 40 alleles （all P 〈 0.01, Pe 〈 0.05） and a decreased frequency of HLA-A＊30 and 33 in patients with asymptomatie syphilis （P -= 0.002, 0.026, Pc = 0.001, 0.013 respectively）, compared with the normal human controls. The frequency of HLA-A＊30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatie syphilis （P = 0.001, Pc = 0.013）. Conclusions There seems to he an association between HLA-A＊02, B＊15 and B＊40 alleles and syphilis, between HLA-A＊30 allele and symptomic syphilis, and between HLA-A＊02, 11 and 29 alleles and asymptomatic syphilis, in Shandong Han population.

关 键 词：梅毒 HLA抗原 等位基因 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]