谷胱甘肽S-转移酶-π与肿瘤多药耐药的研究进展  

Advances in Relationship between Glutathione S-transferase-π and Multidrug Resistance

作　　者：王慧群[1] 张开光[1] 

机构地区：[1]安徽医科大学附属省立医院消化内科

出　　处：《胃肠病学》2010年第12期755-757,共3页Chinese Journal of Gastroenterology

摘　　要：肿瘤多药耐药（MDR）是造成肿瘤化疗失败的主要因为,亦是近年肿瘤化疗的研究热点.随着对非P-糖蛋白（P-gp）介导的MDR机制研究的不断深入,证实谷胱甘肽S-转移酶-π（GST-π）在肿瘤MDR中发挥重要作用,有望成为新的肿瘤治疗靶点.本文就GST-π的生理特性、分布、耐药机制、检测手段和逆转由GST-π介导的MDR等方面作一综述.Multidrug resistance （MDR） is the main cause of failure of tumor chemotherapy, and is a hot spot of research in cancer chemotherapy in recent years. With the deepening study on the mechanism of non-P-glycoprotein （P-gp） mediated MDR, glutathione S-transferase-π （GST-π） has been demonstrated playing an important role in tumor MDR, which might be a new therapeutic target. This article reviewed the physiological characteristics, distribution, MDR mechanisms, detection means of GST-π and the reverse of MDR mediated by GST-π.

关 键 词：抗药性 肿瘤 谷胱甘肽S-转移酶pi P糖蛋白 

分 类 号：R730.5[医药卫生—肿瘤]