microRNA在食管癌中的研究进展  

Advances in Study on microRNA in Esophageal Cancer

作　　者：罗君[1,2,3] 凌志强[2] 毛伟敏[2] 

机构地区：[1]浙江中医药大学第一临床医学院,310006 [2]浙江省肿瘤医院 浙江省肿瘤研究所 [3]浙江省肿瘤医院浙江省肿瘤研究所

出　　处：《胃肠病学》2010年第12期758-760,共3页Chinese Journal of Gastroenterology

基　　金：浙江省自然科学基金项目(Y2091110);卫生部科学研究基金-浙江省医药卫生重大科技计划(WKJ2010-2-004)资助

摘　　要：食管癌是常见的消化道恶性肿瘤,由于早期诊断率低和治疗缺乏靶向性,目前仍无法改变多数食管癌患者预后不良的结局.微RNA（miRNA）是一类长约21～25个核苷酸的内源性非编码小分子单链RNA,可通过抑制靶基因mRNA翻译或促使其降解,调控体内多种重要生理功能,并与肿瘤的发生、发展密切相关.本文对miRNA在肿瘤形成中的作用、食管癌相关miRNA以及miRNA在食管癌诊治中的潜在作用作一综述.Esophageal cancer is a common gastrointestinal malignant disease that has poor prognosis in most patients due to low early diagnosis rate and lack of targeted therapy, mieroRNA （miRNA） is a kind of endogenous small noncoding single-stranded RNA with 21-25 nueleotides, which plays an important role in the regulation of many signifieant physiological functions by inhibiting mRNA translation of target genes or promoting their degradation, and has close relation with the genesis and development of tumor. This article reviewed the roles of miRNA in cancer development, the esophageal cancer related miRNA and its potential effect in diagnosis and treatment of esophageal cancer.

关 键 词：微RNAS 食管肿瘤 诊断 治疗 

分 类 号：R735.1[医药卫生—肿瘤]