Survivin检测在肺癌胸腔积液诊断中的临床价值  

Diagnostic value of Survivin in pulmonary cancerous pleural effusion

作　　者：郝可可[1] 朱际平[2] 于力克[1] 

机构地区：[1]南京市胸科医院呼吸一科,南京200029 [2]江苏省中医院呼吸内科,南京210029

出　　处：《山东大学学报（医学版）》2010年第12期129-133,共5页Journal of Shandong University:Health Sciences

基　　金：南京市医学科技发展重大项目基金"中国人非小细胞肺肿瘤个体化治疗的分子预测研究"资助

摘　　要：目的研究胸水中Survivin含量测定对肺癌性胸腔积液诊断的临床意义。方法收集102例经病理确诊的肺癌伴胸腔积液患者的胸水作为肿瘤组,以87例结核性渗出性胸膜炎患者的胸水为结核组。以ELISA法检测2组胸水中的Survivin含量,同时检测胸水中CEA、NSE、CYFRA21-1的含量并对结果进行统计学分析。结果肿瘤组胸水Survivin的含量为(52.290±41.421)pg/mL,与结核组胸水Survivin的含量(17.286±16.734)pg/mL相比明显升高,差异有统计学意义(P<0.01),其敏感性高于胸水CEA、NSE、CYFRA21-1等肿瘤标志物的检测。结论胸水中Survivin检测可作为肺癌所致胸腔积液诊断的一个敏感指标,具有一定临床实用价值。Objective To investigate the diagnostic value of survivin determination in pulmonary cancerous pleural effusion.Methods Pleural fluid specimens were collected from 102 patients with lung cancer and 87 patients with tuberculous pleurisy.Survivn was determined by ELISA.And the levels of CEA,NSE,and CYFRA21-1 were detected in the pleural effusion.The results were analyzed with statistical methods.Results The survivn level of the malignant pleural effusion was 52.290±41.421 pg/mL,which was significantly higher than that of the tuberculous pleural effusion（17.286±16.734 pg/mL）（P〈0.01）.Survivin is more sensitive in the detemination of pleural effusion than the other three tumor markers（CEA,NSE,and CYFRA21-1）.Conclusion Survivin may be used as a new sensitive and significant marker for diagnosis of lung cancer.

关 键 词：SURVIVIN 胸腔积液 肺肿瘤 诊断 

分 类 号：R734[医药卫生—肿瘤]