人格特质对抑郁症患者临床疗效的影响  

Influence of personality traits on clinical outcomes in depressive patients

作　　者：赵蕾[1] 焦志安[2] 陈伊莎[3] 赵国庆[2] 

机构地区：[1]山东大学医学院,济南250012 [2]山东大学附属省立医院临床心理科,济南250021 [3]山东中医药大学,济南250355

出　　处：《山东大学学报（医学版）》2010年第12期138-141,145,共5页Journal of Shandong University:Health Sciences

摘　　要：目的探讨抑郁症患者的人格特质对临床疗效的影响。方法采用NEO个性问卷对72例抑郁症患者和67例正常对照者进行测试,病例组给予艾司西酞普兰治疗8周,采用汉密尔顿抑郁量表和汉密尔顿焦虑量表在治疗前后评估病例组的抑郁严重程度。结果抑郁症患者在多个人格维度和特质层面上与正常对照者之间存在统计学差异(P<0.05),并且抑郁严重程度与N1显著相关(r=0.415)。在NEO个性问卷中N1、N3、C、C3与抑郁症患者治疗8周末汉密尔顿抑郁量表减分率明显相关。结论抑郁症患者与正常人人格特质有明显差异。用人格特质可以预测抑郁症患者的临床疗效。Objective To explore the impact of personality traits of depressive patients on clinical outcomes.Methods Personality traits were evaluated with the Revised NEO Personality Inventory（NEO-PI-R）in depressive outpatients（n=72）and controls（n=67）.The patients were treated with escitalopram for 8 weeks.Severity of depression was assessed before and after treatment by Hamilton Depression Scale（HAMD）and Hamilton Anxiety Scale（HAMA）.Results The patients with depression had a significantly different personality profile at the baseline compared with the healthy controls（P〈0.05）and the severity of their illness correlated with high scores in anxiety facet（N1）（r=0.415）.The NEO-PI-R showed that N1,N3,C and C3 were strongly associated with score reduced rates of HAMD at the end of the 8th week.Conclusion There are significant differences in personality traits between depressive patients and healthy controls.Personality traits may predict the clinical outcome in depressive patients.

关 键 词：NEO个性问卷 人格 抑郁 

分 类 号：R-749[医药卫生]