变异链球菌二元信号传导系统的研究进展  

Research advancement on two-component signal transduction systems of Streptococcus mutans

作　　者：季晓黎[1] 于丹妮[1] 

机构地区：[1]天津医科大学第二医院口腔内科,天津300211

出　　处：《牙体牙髓牙周病学杂志》2010年第12期724-727,733,共5页Chinese Journal of Conservative Dentistry

摘　　要：二元信号传导系统是变异链球菌感应外界环境变化并对相应基因表达进行调节的主要机制。它是由感应组氨酸激酶和反应调节因子组成的,通过磷酸化作用来对信号进行传送。目前在变异链球菌基因组中已发现了13种二元信号传导系统和1种孤儿调节因子,它们在变异链球菌的酸耐受性、生物膜的形成、感受态发育、应激耐受等致病机制中起着重要的作用。该文就近年来关于变异链球菌二元信号传导系统的研究进展作一综述。Streptococcus mutans uses two-component signal transduction systems to monitor various environmental stimulus and regulate the target genes.The system comprises sensor histidine kinase and response regulator.And the form of signal trusduction is phosphorylation.Until present,13 putative two-component signal transduction systems and 1 orphan response regulator have been found.These systems play a key role in acid resistance reaction,biofilm formation,competence development and stress response.

关 键 词：变异链球菌 二元信号传导系统 耐酸反应 生物膜 感受态发育 应激反应 

分 类 号：R780.2[医药卫生—口腔医学]