22例原发筛窦恶性肿瘤的临床特点及预后分析  

Clinical Characteristics and Prognosis of Primary Ethmoid Sinus Malignant Tumor

作　　者：姜战胜[1] 兰岚[1] 潘战宇[1] 谢广茹[1] 

机构地区：[1]天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院中西医结合肿瘤科,天津市300060

出　　处：《中国肿瘤临床》2010年第24期1455-1458,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨原发筛窦恶性肿瘤的临床特征、诊治要点及预后,旨在提高对本病的认识,做到早期诊断和恰当治疗。方法:回顾性分析本院1984年1月至2004年12月收治的有完整随访资料的22例原发筛窦恶性肿瘤患者的临床资料。分别对性别、年龄、临床分期、治疗方式和病理类型等因素进行预后分析。Kaplan-Meier法计算生存率,Log-rank法进行生存率比较,Cox比例风险回归模型进行单因素和多因素分析。结果:22例患者中,男12例,女10例。发病年龄10～72岁,中位年龄41岁。鳞癌10例,其他病理类型12例。平均随访时间43个月(5～108个月)。全组患者1、3、5年生存率分别为70.2%、54.0%、32.4%。单因素分析显示临床分期(P=0.045)和治疗方式(P=0.026)是影响预后的因素,鳞癌与其他罕见病理类型的5年生存率之间比较没有统计学意义(P=0.4)。结论:原发筛窦恶性肿瘤发病率低,缺乏特异性临床表征,诊断主要依赖CT扫描和术后病理。鳞癌是最常见的病理类型。影响其预后的主要因素是临床分期与治疗方式。手术加放疗是最佳治疗方式。Objective： To analyze the clinical features, diagnostic management and prognosis of primary ethmoid sinus malignant tumor in order to diagnose it earlier and treat it correctly. Methods： Clinical data from 22 patients with primary eth- moid sinus malignancy treated in our hospital between January 1984 and December 2004 were reviewed. All follow-up da- ta was completely attained and recorded. Gender, age, clinical stage, pathological type, treatment method and survival da- ta were analyzed respectively. Survival analysis was conducted with Kaplan-Meier method and Log-rank test was used to compare the survival rates. Univariate and multivariate factors for survival were analyzed by Cox proportional hazards re- gression model. Results： There were 12 male and 10 female patients, aged from 10 to 72 years, with an average of 42. Ten cases were diagnosed as squamous cell carcinoma and the other 12 cases were diagnosed as other pathological types. The average follow-up time was 43 months （5~108 months）. The overall 1-year, 3-year and 5-year survival rates were 70.2%, 54.0% and 32.4% respectively. Univariate analysis showed that clinical stage （P = 0.045） and treatment （P = 0.026） were prognostic factors. The 5-year survival rate of squamous cell carcinoma was not significantly different compared with other less common histological types （P = 0.4）. Conclusion： The incidence of primary ethmoid sinus malignant tumor is low; and its diagnosis relies mainly on CT scan and postoperative pathology due to the lack of specific clinical features. Squamous cell carcinoma is the most common pathological type. Main factors affecting the prognosis are clinical stages and treatment. Surgery plus radiotherapy is the best treatment choice.

关 键 词：鼻窦肿瘤 筛窦 临床特征 治疗 预后 

分 类 号：R739.6[医药卫生—肿瘤]