勃脉力A注射液对体外循环心脏手术患者肝功能的影响  

Effect of plasmaslyte A on the liver function of patients undergoing cardiac surgery with extracorporeal circulation

作　　者：李斌飞[1] 解小丽[1] 张志刚[1] 程周[1] 廖小卒[1] 罗渭康[1] 

机构地区：[1]中山大学附属中山医院麻醉科,广东中山528403

出　　处：《南方医科大学学报》2010年第11期2588-2589,共2页Journal of Southern Medical University

摘　　要：目的探讨勃脉力A注射液对体外循环心脏手术患者肝功能的影响。方法选择术前肝功能正常、无肝炎病史的行体外循环心脏手术患者60名,随机分为勃脉力A组(P组)和林格液组(R组)。所有患者均在术前、术后2h、1d、3d、7d分别采肘正中静脉血和桡动脉血:静脉血分离血清后应用自动血生化分析仪检测血清中天冬氨酸转氨酶和丙氨酸氨基转移酶,以了解患者的肝脏功能改变;抽取动脉血查乳酸浓度。术中及术后密切观察患者血压、心率、中心静脉压、尿量等,观察并记录患者拔管及停留ICU时间。结果与R组相比较,在术后各时间点P组ALT、AST及乳酸浓度均显著降低(P<0.05),并且拔除气管导管时间和停留ICU时间均有所缩短。结论勃脉力A注射液能够显著降低体外循环术中乳酸浓度,并能改善患者肝功能,非常适用于体外循环手术。Objective To observe the effect of plasmaslyte A on the liver function of patients receiving cardiac surgery with extracorporeal circulation.Methods Sixty patients scheduled for cardiac surgery were randomized to receive plasmaslyte A（group P,n=30） and ringer lactate solution（group R,n=30）.The two agents were used in priming heart-lung machine and intra-and postoperative crystal solution.All the patients were examined for the levels of AST,ALT and Lac the day before and at 2 h and 1,3 and 7 days after the surgery.The time of extubation and length of stay at the ICU were record.Results The levels of ALT,AST and Lac in group P were significantly lower than those in group R（P〈0.05）,and the duration of intubation and stay at the ICU was shorter in group P（P〈0.05）.Conclusion Plasmaslyte A can markedly reduce the level of AST,ALT and Lac and protect the liver function of patients undergoing cardiac surgery with extracorporeal circulation.

关 键 词：勃脉力A注射液 天冬氨酸转氨酶 丙氨酸氨基转移酶 乳酸 心脏手术 

分 类 号：R654.2[医药卫生—外科学]