载脂蛋白E与癫痫的关系  

Association between Apolipoprotein E and Epilepsy

作　　者：张岱威(综述)[1] 郑维红(审阅)[1] 

机构地区：[1]厦门大学附属中山医院神经内科,福建省厦门市361004

出　　处：《医学分子生物学杂志》2010年第6期528-530,共3页Journal of Medical Molecular Biology

基　　金：福建省厦门市科技局资助项目（No.3502Z20084019）

摘　　要：载脂蛋白E（apolipoprotein E,ApoE）在中枢神经系统修复受损细胞膜、轴索生长和突触形成的过程中起重要作用.研究证明,在外伤、中毒、免疫应答以及痫性放电引起的脑部损伤的病灶组织中都存在载脂蛋白E表达的上调现象.载脂蛋白E的基因多态性和表达量与难治性癫痫的发生和发展有一定的相关性,提示载脂蛋白E的异常可能是难治性癫痫产生机制中的一个重要环节.Apolipoprotein E is an important lipoprotein. It plays a significant role in cytomembrane repair, neurite growth and new synapses development. Research has shown that the expression of Apolipoprotein E would increase in brain＇s damage, such as cranial trauma, poisoning, immune response and seizures. The association between Apolipoprotein E and epilepsy, especially refractory epilepsy, is still unclear. Several studies have investigated this association, and they suggested that abnormal apolipoprotein E plays a key role in the development of refractory epilepsy.

关 键 词：载脂蛋白E 难治性癫痫 颞叶癫痫 

分 类 号：R741[医药卫生—神经病学与精神病学]