纵隔灰区淋巴瘤的研究进展  

Advance on mediastinal gray zone lymphoma

作　　者：樊妮(综述)[1] 许小平(审校)[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040

出　　处：《白血病．淋巴瘤》2011年第3期182-185,共4页Journal of Leukemia & Lymphoma

摘　　要：纵隔灰区淋巴瘤（mediastinal gray zone lymphoma）作为一个疾病实体，常不能依据现有的诊断标准进行分类。这类淋巴瘤同时具有纵隔弥漫大B细胞淋巴瘤（PMBL）和经典霍奇金淋巴瘤（cHL）的特征。在2008年WHO造血与淋巴组织肿瘤分类中将其命名为“B细胞淋巴瘤，不能分类，具有介于弥漫大B细胞淋巴瘤和经典霍奇金淋巴瘤之间的特征（BCLu）”。BCLu具有独特的临床特点、免疫表型和分子遗传学特征，临床过程更具侵袭性，预后较差。目前尚无达成共识的治疗方案，可参照侵袭性B细胞淋巴瘤的方案化疗。As a distinct clinicopathological entity, mediastinal gray zone lymphoma cannot be classified by using differential diagnostic criteria. The cases represent a spectrum of tumors having characteristics of both primary mediastinal large B-cell lymphoma （PMBL） and classic Hodgkin lymphoma （cHL）. In the 2008 WHO Classification, a novel category designated B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma （BCLu） has been created to include these neoplasms. The main features of BCLu are clearly different from those of conventional mediastinal large B-cell lymphomas. Diagnosis of BCLu requires a multiparameter approach incorporating morphological, immunophenotypic, immunohistochemical and other features. These lymphomas generally have a more aggressive clinical course and poorer outcome. There is no consensus on the optimum treatment, while the recommended therapies for aggressive B-cell lymphomas might be effective options.

关 键 词：灰区淋巴瘤 淋巴瘤 非霍奇金 诊断 鉴别 

分 类 号：R733.1[医药卫生—肿瘤]