同型半胱氨酸在肝脏疾病中的诊断价值  

Value of homocysteine in diagnosis of liver diseases

作　　者：门莎莎[1] 田亚平[1] 董振南[1] 

机构地区：[1]解放军总医院生化科,北京100853

出　　处：《军医进修学院学报》2011年第4期325-326,408,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家科技支撑计划课题项目(2009BAI86B05)~~

摘　　要：目的探索同型半胱氨酸(Hcy)在肝脏疾病中的诊断价值。方法观察37例乙型肝炎患者,29例肝硬化患者,45例原发性肝细胞癌患者以及35例正常对照组血清中丙氨酸氨基转移酶,天冬氨酸氨基转移酶,白蛋白,总胆汁酸,总胆红素和同型半胱氨酸水平的差异,分析同型半胱氨酸用于诊断原发性肝癌的灵敏性和特异性。结果各项生化指标与对照组相比,乙肝组白蛋白、总胆汁酸和同型半胱氨酸以及肝硬化组Hcy差异无统计学意义(P>0.05),其余差异均有统计学意义(P<0.05);同型半胱氨酸水平与天冬氨酸氨基转移酶和总胆红素呈正相关;同型半胱氨酸用于原发性肝细胞癌诊断时,ROC曲线下面积为A=0.70,且当其临界值取0.14时诊断敏感性为62.2%、特异性为94.3%。结论同型半胱氨酸可作为反映肝脏疾病的生化指标之一,且对原发性肝细胞癌具有一定的诊断价值。Objective To study the value of homocysteine（Hcy） in diagnosis of liver diseases.Methods Different serum ALT,AST,ALB,TBA,TB,and Hcy levels were observed in 37 patients with hepatitis B,29 patients with liver cirrhosis（LC）,45 patients with primary hepatocellular carcinoma（HCC）,and 35 normal controls.The sensitivity and specificity of Hcy in diagnosis of primary HCC were analyzed.Results No statistical difference was found in serum ALB,TBA and Hcy levels between patients with hepatitis B and those with LC（P0.05）.However,a statistical difference was found in other biochemical indicators between patients with hepatitis B and those with LC（P0.05）.The Hcy level was positively correlated with the AST and TB level.The area under the ROC curve was 0.70 when Hcy was used in diagnosis of HCC,with sensitivity of 62.2% and a specificity of 94.3% when the critical value was set at 0.14.Conclusion Hcy can be used as a biochemical marker of liver diseases and has a certain value in diagnosis of primary HCC.

关 键 词：同型半胱氨酸 肝疾病 灵敏性 特异性 

分 类 号：R575.2[医药卫生—消化系统]