阿尔茨海默病患者体内端粒长度与氧化应激关系  

Correlation between oxidation stress and telomere length in patients with Alzheimer's disease

作　　者：管静芝[1] 管维平[2] 朱文华[1] 

机构地区：[1]解放军309医院肿瘤科,北京100091 [2]解放军总医院南楼神经内科,北京100853

出　　处：《军医进修学院学报》2011年第4期375-377,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的探讨阿尔茨海默病(Alzheimers′disease,AD)患者与脂质过氧化应激相关的端粒长度变化。方法 40名AD患者,59名年龄相当的正常对照。分别测定所有受试者尿液中8-异前列腺素F2α(8-iso-prostaglandin F2alpha,8-iso-PGF2α)的浓度,外周血单核细胞端粒长度,包括端粒平均长度与端粒长度分布。结果 AD患者尿8-iso-PGF2α的水平明显高于对照组,(71.68±2.60)ng/mmol vs(46.90±1.88)ng/mmol creatinine(P<0.001),端粒平均长度差异无统计学意义,但稍长端粒(4.4-9.4kb)比例明显增加,短端粒(<4.4kb)比例减少。结论 AD患者体内氧化应激较对照组增高;端粒长度分布呈现氧化应激相关的变化,最短端粒对氧化应激更敏感。Objective To study the lipid peroxidation-related changes of telomere length in patients with Alzheimer＇s disease（AD）.Methods Forty AD patients（experimental group） and 59 healthy subjects（control group） were enrolled in this study.Concentration of 8-iso-prostaglandin F2α（8-iso-PGF2α） in urine and telomere length in peripheral mononuclear cells（including average length of telomere and its distribution） were measured,respectively.Results The urinary 8-iso-PGF2α level was statistically higher in AD patients than in controls（71.68±2.60）ng/mmol vs（46.90±1.88）ng/mmol creatinine（P0.001） with no difference observed in the mean length of telomeres.However,the ratio of slightly longer telomeres（4.4-9.4kb） was increased,while that of short telomeres（4.4kb） was decreased in AD patients.Conclusion The oxidation stress level is statistically higher in AD patients than in controls.The distribution of telomere length is related with the oxidation stress-related change.The shortest telomeres are more sensitive to oxidation stress.

关 键 词：阿尔茨海默病 端粒 脂质过氧化作用 

分 类 号：R742.1[医药卫生—神经病学与精神病学]