硫酸镁联合小剂量促肾上腺皮质激素治疗婴儿痉挛症  

The Treatment Effect of Magnesium Sulfate Combined with a Low Dose Adrenocorticotrophic Hormone for the Infantile Spasms

作　　者：李乔俊[1] 蔡笑[1] 徐飞[1] 

机构地区：[1]解放军总医院第一附属医院,北京100048

出　　处：《儿科药学杂志》2011年第2期22-23,共2页Journal of Pediatric Pharmacy

摘　　要：目的:评价硫酸镁联合小剂量促肾上腺皮质激素(ACTH)治疗婴儿痉挛症的疗效及不良反应。方法:采用随机对照研究将15例婴儿痉挛症患儿随机分为治疗组7例,给予硫酸镁联合小剂量ACTH治疗,对照组8例单用ACTH治疗,评价痉挛发作和脑电图恢复情况,同时观察不良反应。结果:3个月、6个月随访,7例联合治疗患儿中有5例取得良好疗效,8例单用ACTH治疗患儿中4例控制良好;联合治疗组和对照组均有3例发生不良反应。结论:提倡ACTH从小剂量开始,并注意输液速度的调整,硫酸镁可以作为婴儿痉挛症治疗的辅助用药。Objective：To evaluate the curative effect and side effect of magnesium sulfate combined with a low dose Adrenocorticotrophic hormone（ACTH） for the infantile spasms.Methods：Dividing 15 cases into two groups,to evaluate general convulsive seizure and EEG of 7 cases of infantile spasms treated with magnesium sulfate and a low dose ACTH and 8 cases with ACTH only,and to observe side effects in the meantime.Results： At 3 months and 6 months,5 patients（71.4%） who received ACTH ＋ magnesium sulfate and 4 patients（50%） who received ACTH only were seizure free.There were 3 cases of adverse reactions in each group.Conclusions： A low dose ACTH is advocated and the liquid speed needs to be noticed,magnesium sulfate can be an assistant treatment for the infantile spasms.

关 键 词：硫酸镁 促肾上腺皮质激素 婴儿 痉挛症 

分 类 号：R743.31[医药卫生—神经病学与精神病学]