大豆异黄酮对AD大鼠海马PS-1表达的影响  

Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer's Disease

作　　者：方正清[1] 刘长安[1] 汪远金[1] 朱洁[1] 白玫[1] 

机构地区：[1]安徽中医学院中西医结合研究所,安徽合肥230038

出　　处：《食品科学》2011年第7期312-314,共3页Food Science

基　　金：安徽省自然科学基金项目(070413259X)

摘　　要：目的:探讨大豆异黄酮(SIF)对AD大鼠海马PS-1表达的影响。方法:采用β-淀粉样蛋白(Aβ)单侧海马注射建立阿尔茨海默病(AD)大鼠模型,给予相应药物后,利用跳台实验观察AD大鼠学习记忆能力的变化,免疫组化检测AD大鼠海马早老素(PS-1)表达。结果:大豆异黄酮可改善AD大鼠的学习记忆能力(P<0.01),显著性降低AD大鼠PS-1表达(P<0.01)。结论:大豆异黄酮显著降低AD大鼠海马组织PS-1表达,从而改善AD大鼠学习记忆能力。Objective：To explore the effect of soybean isoflavone（SIF） on the expression of presenilin protein-1（PS-1） in rats with Alzheimer＇s disease（AD）.Methods：AD rat models were established by unilateral hippocampus injection of Aβ.The changes in learning and memory capability of AD rats were measured by step down test,the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method.Results：Soybean isoflavone（SIF） could improve learning and memory capability of AD rats（P0.01） by step down test,and significantly decrease the expression of PS-1（P0.01） in hippocampus of AD model group.Conclusion：Soybean isoflavone（SIF） can decrease PS-1 expression and improve learning and memory capability of AD rats.

关 键 词：大豆异黄酮 阿尔茨海默病 Β-淀粉样蛋白 PS-1 

分 类 号：R285.5[医药卫生—中药学]