焦炉工人血清中p21蛋白和HSPs水平的研究  

The study on the serum level of p21 and HSPs in workers exposed to coke oven emissions

作　　者：潘秋萍[1] 孙恩林[2] 陈胜[1] 丁焱焱[2] 邬堂春[1] 贺涵贞[1] 张国高[1] 

机构地区：[1]同济医科大学职业医学研究所,武汉430030 [2]武钢工业卫生安全技术研究所

出　　处：《中国职业医学》1999年第5期4-6,共3页China Occupational Medicine

摘　　要：目的　寻找接触焦炉逸散物的焦炉工人肺癌的早期监护指标。方法　用Ｄｏｔ ｂｌｏｔ 方法检测５６ 名焦炉作业工人及３２ 名对照组人群血清中ｒａｓ 基因产物ｐ２１ 蛋白和ＨＳＰ２７ 、ＨＳＰ７０ 的水平。结果　焦炉工人血清的ｐ２１ 蛋白明显高于对照组（ Ｐ＜ ０－０１） ，且其阳性率为３５－７ ％ ，显著高于对照组（１２－５ ％ ，Ｐ＜０－０５） ；相关分析表明，焦炉工ｐ２１ 水平与工人工龄存在极显著相关（ Ｐ＜ ０－００１） 。同时焦炉工人血清ＨＳＰ２７水平也明显高于对照组（ Ｐ＜ ０－０５） ，ＨＳＰ７０ 水平两组间无显著差异。结论　推测血清中ｐ２１Objective The main aim of this study is to look for early surveillant biomarkers of lung cancer among workers exposed to coke oven emissions (COE) Methods Using Western Dot blotting, the p21 level of ras gene product, HSPs in sera were detected in 56 exposed workers and 32 control ones Results The results showed that the average p21 level of exposed workers was significantly higher than that of the control ( P <0 01) Furthermore, p21 positive rate in exposed workers increased significantly ( P <0 05), and p21 level had strong correlation with working age in exposed worker ( P <0 001) Compared with the control, HSP 27 levels of the exposed workers also increased significantly ( P <0 05), but HSP 70 did not Conclusion It suggested that the level of p21 and HSP27 in sera might have important biological significance in screening of lung cancer for workers exposed to COE

关 键 词：焦炉逸散物 p12蛋白 HSPS 血清 肺癌 

分 类 号：R734.202[医药卫生—肿瘤] R446.112[医药卫生—临床医学]