显微手术联合分泌BMP4的自体MSCs靶向BTSC治疗复发脑胶质瘤  

Treatment of recurrent brain gliomas by microsurgical excision combined with secrete BMP4 autologous MSCs targeted BTSC

作　　者：步星耀[1] 程培训[1] 姜金豆[1] 翟亚萍[1] 丁玉超[1] 陈彩霞[1] 郭晓鹤[1] 刘政国[1] 鲍玉州[1] 

机构地区：[1]河南省人民医院神经外科,郑州450003

出　　处：《医药论坛杂志》2011年第2期10-13,共4页Journal of Medical Forum

基　　金：河南省科技攻关项目(0424410054);河南省杰出人才计划项目(084200410011)资助

摘　　要：目的探讨显微外科手术切除联合分泌BMP4的自体MSCs靶向脑肿瘤干细胞(brain tumor stem cells,BTSC)治疗复发脑胶质瘤的临床疗效和安全性。方法对10例复发脑胶质瘤患者行开颅显微外科手术全切除,术中瘤腔内安置Ommaya囊,术后2 W、4 W、6 W、8 W经由Ommaya囊行瘤腔内给予分泌BMP4的自体MSCs靶向BTSC治疗。随访6～18个月,观察治疗效果。结果 10例患者均获随访,3个月无复发,无死亡;6个月复发3例,死亡1例,生存期明显延长。全部患者均无明显的不良反应,生存质量得到明显改善。结论显微外科手术切除联合分泌BMP4的自体MSCs靶向BTSC治疗复发脑胶质瘤安全显效,值得推广。Objective To investigate the safety and efficacy of treatment of recurrent brain gliomas by surgical excision combined with secrete BMP4 autologous MSCs targeted brain tumor stem cells（BTSC）. Methods In 10 patients with recurrent brain gliomas,the tumor was microsurgically removed and initial Ommaya bursa were embeded in the tumor bed during operation.Postoperation 2,4,6,8 weeks,patients were received secrete BMP4 autologous MSCs by intra-Ommaya.The patients were followed up for 618 months,and the results of treatment were evaluated. Results All of the 10 patients were followed up.At 3 months after treatment,there were no recurrent and mortality.After 6 months,recurrent is 3 of 10 and survival is 9 of 10,life time extended.All the patients had no apparent side-effects and life quality were improved. Conclusions Microsugical resection combined with secrete BMP4 autologous MSCs is the safe and effective method of targeting BTSC for recurrent brain gliomas,which worth extending.

关 键 词：复发脑胶质瘤 显微手术切除 干细胞 骨形态发生蛋白4 靶向治疗 

分 类 号：R739.41[医药卫生—肿瘤]