吗啡成瘾小鼠对正常小鼠学习记忆力能力的影响  

Effects of morphine abstained mice on spatial learning and memory in normal impuberism mice

作　　者：李云霞[1] 勾旬[1] 谢一舟[1] 汪宇辉[1] 刘延友[1] 王正荣[1] 

机构地区：[1]四川大学华西基础医学与法医学院时间生物学卫生部重点实验室,四川成都610041

出　　处：《四川生理科学杂志》2011年第1期1-3,共3页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金资助(编号:30470684)

摘　　要：目的:用BALB/C小鼠建立动物模型,观察吗啡成瘾戒断小鼠对其周围的正常小鼠学习记忆能力的影响。方法:将吗啡成瘾戒断小鼠与正常小鼠同笼饲养,然后用Morris水迷宫实验测定正常小鼠的学习记忆能力,应用RT-PCR的方法检测正常小鼠海马中PKCa、GABA分子表达的变化。结果:水迷宫实验证明,与生理盐水组相比,实验组小鼠的学习记忆能力明显降低(P<0.05),海马中PKCa和DABA的表达都明显升高(P<0.05)。Objective：To study the effects of morphine abstained mice on spatial learning and memory in normal impuberismmice.Methods： The impuberismmice were raised with other morphine abstained mice in the same cage.The spatial learning and memory of the normal mice was evaluated with Morris water maze test.The expressions of PKCaand GABAin hippocampus of the newborn mice were observed by the RT-PCR technique.Results：The experimental group found the platform were faster than that in the control group in Morris water maze test（P〈0.05）.Expressions of PKCa and GABA mRNA had significant differences between experimental groups and control groups.Conclusion： Morphine abstained mice can influence the learning and memory of the normal impuberismmice.

关 键 词：吗啡成瘾 戒断 水迷宫实验 PKCa GABA 

分 类 号：R749.6[医药卫生—神经病学与精神病学]