宁夏回族癫痫患者ABCB1 C3435T与癫痫耐药相关性研究  

Association between ABCB1 C3435T and Drug-resistant Epilepsy in Ningxia Hui Epilepsy Patients

作　　者：董通[1] 许贤瑞[1] 张庆[2] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学附属医院,银川750004

出　　处：《宁夏医科大学学报》2011年第2期108-111,共4页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金重点项目(NZ101127);宁夏回族自治区卫生厅重点科研项目(W2009038)

摘　　要：目的了解宁夏回族癫痫患者ABCB1 C3435T多态性及与癫痫耐药的关系。方法收集宁夏地区回族癫痫患者123例,其中癫痫药物敏感者60例,耐药者63例,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对两组癫痫患者ABCB1基因C3435T位点的多态性进行检测,并分析其与癫痫耐药的关系。结果耐药组CC基因型和C等位基因频率高于敏感组(P<0.01)。结论宁夏回族癫痫患者中ABCB13435CC基因型及C等位基因与癫痫耐药有关,该位点的多态性可能影响癫痫患者对抗癫痫药物的反应性。Objective To explore the association between ABCB1 C3435T Polymorphism and drug-resistant epilepsy in Ningxia Hui ethnic epileptic patients.Methods 123 Hui ethnic epileptic patients were collected,including 60 drug responsive epilepsy patients and 63 drug-resistant epilepsy patients.Polymerase chain reaction restriction fragment length polymorphism（PCR-RFLP） technique was used to detected ABCB1 C3435T polymorphism.The relationship between ABCB1 C3435T Polymorphism and drug-resistant epilepsy was analyzed.Results CC type and allele C in the drug-resistant group was significantly higher（P0.01） than those in the drug responsive group.Conclusion ABCB1 3435CC genotype and C allele showed relevance to drug-resistant epilepsy in Ningxia Hui population,and these Polymorphism could affect responsive to antiepileptic drugs（AEDs） in epilepsy treatment.

关 键 词：ABCB1 C3435T 癫痫耐药 回族 

分 类 号：R742.1[医药卫生—神经病学与精神病学]