过敏性紫癜患儿外周血IL-16、IL-18水平的研究  

Study on IL-16 and IL-18 in peripheral blood mononuclear cells of children with Henoch-schonlein purpura

作　　者：李禹兵[1] 刘延香[1] 

机构地区：[1]延安大学附属医院血液免疫科,陕西延安716000

出　　处：《西部医学》2011年第4期661-662,共2页Medical Journal of West China

摘　　要：目的探讨IL-16、IL-18在过敏性紫癜患儿中的应用价值。方法采用固相酶联免疫分析法检测69例过敏性紫癜患儿血清IL-16、IL-18水平。结果过敏性紫癜急性期患儿血清IL-16、IL-18较健康对照组明显升高(P<0.01),而过敏性紫癜缓解期患儿与健康对照组间无显著差异(P>0.05),过敏性紫癜患儿IL-16与IL-18呈正相关。结论 IL-16、IL-18可能参与过敏性紫癜血管炎的发病,IL-16、IL-18的检测与过敏性紫癜病情发展有一定关系。Objective To investigate the clinical significance of IL-16 and IL-18 in Henoch-schonein purpur（HSP）children.MethodsAn enzyme-linked immunosorbent assay（ELISA）was utilized to detect the levels of IL-16 and IL-18 in serum of 69 children with HSP.ResultsStatistical analysis showed that the serum levels of IL-16 and IL-18 in HSP were significantly higher than those of healthy control respectively（P〈0.01）,while there was no significance between recessive HSP and healthy control（P〉0.05）.The levels of IL-16 were correlated with IL-16.ConclusionIL-16 and IL-18 might play an important role in the pathogenesis of HSP,and they are associated with the disease activity of HSP.

关 键 词：过敏性紫癜 固相酶联免疫法 IL-16 IL-18 

分 类 号：R730.3[医药卫生—肿瘤]