载药纳米粒作为脑靶向给药系统的研究  

Study on nanoparticle systems for brain target delivery of drugs

作　　者：高冰[1] 陶毅[1] 张宏亮[1] 苏政权[2] 

机构地区：[1]广东药学院药科学院,广州510006 [2]广东药学院公共卫生学院,广州510240

出　　处：《现代生物医学进展》2011年第5期949-954,共6页Progress in Modern Biomedicine

基　　金：广东省科技计划项目(2009B020313006);广东省科技计划项目(2010B090400467);中山市科技计划项目(2009H017)

摘　　要：血脑屏障使大部分的活性药物很难由血液进入脑内发挥作用。载药纳米粒具有脑靶向性,可显著提高药物在脑内浓度,成为药物突破血脑屏障的有效途径。本文综述了近年来载药纳米粒透过血脑屏障的研究进展,并对纳米粒载中药入脑提出展望。Most active drugs were kept from entering in the brain because of the blood-brain barrier（BBB）.The drug loaded nanoparticles have brain targeting quality so that the drugs＇ concentrations in brain could be outstandingly improved and it＇s becoming an possible effective way to break through the difficult in drugs＇ permeation into BBB.This review summarizes the research progress of drug loaded nanoparticles permeating the BBB and envisages the possibility of Chinese drugs loaded nanoparticles permeating the BBB.

关 键 词：血脑屏障 纳米粒 脑靶向 

分 类 号：R914.2[医药卫生—药物化学]