不同剂量丁二磺酸腺苷蛋氨酸治疗慢性肝内胆汁淤积的疗效观察  

The observation of ademetionine 1, 4.butanedisulfonate of different dosage on chronic intra-hepatic cholestasis

作　　者：吴萍[1] 武侠[1] 张葆[1] 鹿博[1] 

机构地区：[1]江苏省徐州市中心医院消化科,221009

出　　处：《中国医药》2011年第4期402-403,共2页China Medicine

摘　　要：目的 观察不同剂量丁二磺酸腺苷蛋氨酸治疗慢性肝内胆汁淤积的临床效果.方法 将80例肝内胆汁淤积患者按住院号随机分成3个观察亚组及1个对照组,每组20例.在基础治疗相同情况下,500 mg/d亚组予丁二磺酸腺苷蛋氨酸500 mg/d,1000 mg/d亚组予丁二磺酸腺苷蛋氨酸1000 mg/d,2000 mg/d亚组予丁二磺酸腺苷蛋氨酸2000 mg/d,对照组则给予门冬氨酸钾镁,4周为1个疗程.4组均分别检测治疗前、治疗1周、治疗2周和治疗4周后血清总胆红素（TBIL）并进行对比.结果 500 mg/d、1000 mg/d、2000 mg/d亚组治疗1、2、4周后TBIL水平[（198±47）、（132±33）、（81±22）μmol/L,（135±38）、（100±20）、（70±35）μmol/L,（100±51）、（67±23）、（30±12）μmol/L]及对照组治疗2、4周后TBIL水平[（180±33）、（153±33）μmol/L]与治疗前[（268±101）、（272±82）、（262±90）、（256±88）μmol/L]比较,差异均有统计学意义（P＜0.01）.各观察亚组治疗1、2、4周后TBIL水平和对照组相应治疗时间比较,差异均有统计学意义（均P＜0.01）.各观察亚组之间,治疗1、2、4周后TBIL水平比较,差异均有统计学意义（均P＜0.05）.500、1000、2000 mg/d观察亚组的总有效率分别为85.5%、95.5%、100.0%,对照组为45.0%,各观察亚组与对照组比较,差异均有统计学意义（均P＜0.01）.治疗过程无明显不良反应.结论 丁二磺酸腺苷蛋氨酸治疗慢性肝内胆汁淤积疗效较理想,没有明显不良反应,在试验剂量范围内,随着剂量的增加,疗效也增加.Objective To observe the therapeutic effect and side effects of varied dosage of ademetionine 1,4-butanedisulfonate for chronic intra-hepatic cholestasis. Methods Eighty intra-hepatic cholestasis patients were divided into four groups. Under the same basic treatment, patients in the treatment group were treated with ademetionine 1, 4-butanedisulfonate 500 mg/d, 1000 mg/d and 2000 mg/d. Patients in the control group were treated with potassium-magneium aspartate injection with a course for 4 weeks. The changes of litude of serum total bilirubin （TBIL） , serum conjugated bilirubin （SCB） were observed before therapy and 1,2, 4 weeks after therapy. Results After 1 week, 2 weeks, 4 weeks treatment with ademetionine 1,4-butanedisulfonate of different dosage, the degression altitude of TBIL, SCB showed significant differences （P 〈0.01, P 〈0.05）. The therapy effective rates of ademetionine 1, 4-butanedisulfonate of different dosage were all higher that those in the control group. There were not significant differences of side effects. Conclusion The therapeutic effect of ademetionine 1,4-butanedisulfonate in the chronic intra-hepatic cholestasis is superior to magneium aspartate.

关 键 词：胆汁淤积 肝内 丁二磺酸腺苷蛋氨酸 门冬氨酸钾镁 

分 类 号：R575[医药卫生—消化系统]