小剂量多西环素治疗慢性牙周炎的疗效和对基质金属蛋白酶8的影响  

Effect of low-dose doxycycline on the level of gingival crevicular fluid matrix metalloproteinases-8 in chronic periodontitis

作　　者：赵文华[1] 

机构地区：[1]山东省泰安市中医二院口腔科,271000

出　　处：《中国医药》2011年第4期460-462,共3页China Medicine

摘　　要：目的 探讨小剂量多西环素（LDD）对慢性牙周炎的临床疗效.方法 20例慢性牙周炎患者,均予洁刮治和根面平整术（SRP）治疗,并按随机数字表随机分为LDD和安慰剂2组,各10例.LDD组口服盐酸多西环素片,安慰剂组口服安慰剂,3个月为1个疗程.分别在治疗前和治疗后3、6、9、12个月时检测2组患者的菌斑指数、牙龈指数、探诊深度、附着丧失、龈沟液量及龈沟液中基质金属蛋白酶8（MMP-8）水平,并对2组结果 进行统计学分析.结果 与治疗前比较,治疗后2组菌斑指数、牙龈指数、探诊深度、附着丧失均明显改善,龈沟液量明显减少,MMP-8水平均下降（P＜0.05）.与安慰剂组比较,LDD组的龈沟液量和MMP-8治疗后6个月下降明显[（0.13±0.02）μl比（0.29±0.02）μl;（3.7±3.2）ng/30 s比（12.3±4.1）ng/30 s,P＜0.05],牙龈指数、探诊深度在治疗后9、12个月改善更为明显[（0.65±0.25）比（1.25±0.13）;（0.70±0.24）比（1.20±0.18）;（2.54±0.18）mm比（3.22±0.12）mm;（2.25±0.17）m比（3.18±0.13）mm],差异均有统计学意义（均P＜0.05）.结论 牙周基础治疗联合小剂量多西环素,能明显改善慢性牙周炎患者的临床症状,而这与其能降低龈沟液中MMP-8水平有关.Objective To investigate the effect of low-dose doxycycline（LDD）on the level of gingival crev icular fluid（GCF） matrix metalloproteinases-8 （ MMP-8 ） in chronic periodontitis. Methods Twenty patients with chronic periodontitis were selected and randomly divided into two groups（ n = 10 in each group）. After scaling and root planning（ SRP）, the SRP ＋ LDD group received LDD for 3 months, whereas the SRP ＋ P group received placebo 3 months. The patients were evaluated every 3 months during the 12-month study period. The plaque index（ PLI）, gingival index（ GI）, probing depth（ PD）, attachment loss（AL） and GCF samples were collected at each visit. The level of MMP-8 were detected and analyzed. Results Compared to baseline, the scores of PLI, GI, PD, AL and MM P-8 of the two groups showed statistically improvement during the 12-month study period （P 〈 0.05 ）. Compared to the SRP ＋ P group, the SRP ＋ LDD group showed statistically differences of GI, PD at 9,12-month visit. Conclu sion Adjunctive SDD therapy can improve the clinical parameters and this clinical improvement is reflected by level of MMP-8 in chronic periodontitis after the therapy.

关 键 词：牙周炎 龈沟液 多西环素 基质金属蛋白酶类 

分 类 号：R781.4[医药卫生—口腔医学]