KAI-1和MMP-9在鼻咽癌组织的表达及相关性  

Expression and Correlation of KAI-1 and MMP-9 in Nasopharyngeal Carcinoma Tissues

作　　者：蔡良真[1] 支梅芬[1] 何文艳[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,广东湛江524000

出　　处：《中国现代医生》2011年第8期26-27,50,共3页China Modern Doctor

摘　　要：目的探讨KAI-1和MMP-9在鼻咽癌组织的表达及其相关性。方法通过免疫组化S-P法检测KAI-1和MMP-9在23例慢性鼻咽炎、62例鼻咽癌组织(其中38例伴有颈部淋巴结转移)中的表达情况。结果 KAI-1和MMP-9在鼻咽癌组织阳性率分别为56.5%、75.8%,两者在慢性鼻咽炎的阳性率分别为100%、13.0%,差异均有统计学意义(P<0.05);鼻咽癌转移组KAI-1的阳性表达明显低于非转移组,阳性率分别为39.5%、83.3%(P<0.05)。鼻咽癌转移组MMP-9表达明显高于非转移组,阳性率分别为89.4%、54.2%,差异有统计学意义(P<0.05)。鼻咽癌淋巴结转移组中KAI-1和MMP-9表达无相关(P>0.05)。结论 KAI-1和MMP-9在鼻咽癌组织中异常表达,联合检测有助于进一步阐明鼻咽癌的发生、发展机制。Objective To study the expressions and correlation of KAI-1 and MMP-9 in nasopharyngeal carcinoma（NPC）. Meth- ods S-P immunohistochemical method was used to detect the expressions of KAI-1 and MMP-9 in 23 chronic nasopharyngitis and 65 NPCs （38 cases with lymph node metastases）. Results The positive expression rates of KAI-1 and MMP-9 were 56.5% and 75.8% in 65 NPCs,while were 100% and 13.0% in 23 chronic nasopharyngitis,respectively,and there was significant difference （P〈0.05）. The positive expression rates of KAI-1 in metastasis group was lower than those of and non-metastasis group,were 39.5% and 83.3%, respectively,showing significant difference （P〈0.05）. Expression of MMP-9 in metastasis group was higher than in non-metastasis group,those rates were 89.4% and 54.2%. There was on correlation between the expression of KAI-1 and MMP-9 in lymph node metastases of NPC （P〉0.05）. Conclusion KAI-1 and MMP-9 express abnormally in NPC,combined them help to further clarify the development of mechanisms of NPC.

关 键 词：鼻咽癌 KAI-1 MMP-9 转移 

分 类 号：R739.6[医药卫生—肿瘤]