羧甲基淀粉的半干法合成及崩解力来源的探讨  

Synthesis of Carboxymethylstarch and Source of Disintegration Force

作　　者：伍焜贤[1] 李若琦[1] 

机构地区：[1]广东药学院,广州510224

出　　处：《西北药学杂志》1999年第5期207-208,共2页Northwest Pharmaceutical Journal

摘　　要：采用半干法合成片剂崩解剂校甲基淀粉（CMS）；考察了氢氧化钠和一氯乙酸用量对CMS取代度（DS）的影响，DS和CMS中游离羧基与成盐羧基比值H／Na改变对CMS吸水溶胀性能的影响，并据此探讨片剂崩解过程中溶胀力的来源。Carboxymethylstarch (CMS) tablets disintegrant was synthesized with hemi-dry process.The influence of the quantity of sodium hydroxyde and chloroacetic acid on the degree of substitution(DS)of CMS and the influence of H/Na(ratio of free and salified carboxyl groups of CMS) on the swelling per-formance of CMS were discussed- The result showed that when DS and H/Na were 0. 56 and 0.13~0.14respectively, CMS possessed the optimal performance of water-absorbing swelling. On the basis of this,the source of disintegration force of CMS was interpreted.

关 键 词：药物 淀粉 羧甲基淀粉 吸水溶胀 崩解 合成 

分 类 号：TQ460.4[化学工程—制药化工]