慢性创伤后应激障碍患者对短期记忆提取任务的脑功能磁共振研究  

A Magnetic Imaging Study of Brain Function in Patients with Chronic Post-traumatic Stress Disorder When Doing Short-term Memory Retrieval Task

作　　者：张丽[1] 李卫晖[1] 李凌江[1] 张燕[1] 贺忠[2] 尹岩[1] 段炼[1] 王利锋[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [2]中南大学湘雅二医院放射科,湖南长沙410011

出　　处：《中国临床心理学杂志》2011年第2期143-145,153,共4页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(30830046);国家科技支撑计划项目(2007BAI17B02);973计划项目(2009CB918303)

摘　　要：目的:探讨慢性创伤后应激障碍(post-traumatic stress disorder,PTSD)患者执行短期记忆提取任务时脑功能的激活特征。方法:对17例矿难相关的慢性PTSD患者和14例经历相同矿难未患病的对照进行脑功能磁共振成像。结果:与对照组比,病例组左海马旁回,右颞上回,左中央后回,右角回,右豆状核的激活降低。结论:慢性PTSD患者存在短期记忆受损的情况。颞叶(包括边缘系统),顶叶,杏仁核可能参与了短时记忆贮存与提取的过程。Objective： To study the feature of brain functional activation in patients with chronic post-traumatic stress disorder（PTSD）when doing short-term memory retrieval task.Methods： 17 miners with chronic PTSD resulting from a severe mining accident and 14 miners exposed to the same accident without PTSD underwent functional magnetic resonance imaging（fMRI）.Results： The PTSD group showed lower activation in left parahippocampal gyrus,right superior temporal gyrus,left postcentral gyrus,right angular gyrus,right lentiform nucleus than non-PTSD controls.Conclusion： It is confirmed by neuroimaging technique that impaired short-term memory existing in patients with chronic PTSD.Temporal lobe（including limbic system）,parietal lobe and lentiform nucleus may be involved in the process of storage and retrieval in short-term memory.

关 键 词：应激障碍 创伤后 磁共振成像 脑 短期记忆 

分 类 号：R395.2[哲学宗教—心理学]