单纯放疗治疗早期喉鳞癌的疗效及预后因素分析  

Analysis of the curative effect and prognostic factors of early stage laryngeal squamous cell cancer treated by irradiation alone

作　　者：鲁萍[1,2] 兰胜民[2] 王宏卫[2] 曹建忠[2] 郭修栋[1,2] 张红云[1,2] 

机构地区：[1]山西医科大学研究生学院,太原030001 [2]山西省肿瘤医院放疗中心,030013

出　　处：《中国医疗前沿》2011年第5期18-19,14,共3页China Healthcare Innovation

摘　　要：目的研究单纯放疗治疗早期喉癌的疗效及预后因素。方法回顾性分析2003年1月-2008年12月在山西省肿瘤医院接受单纯放射治疗的早期喉癌患者85例。用K-M法进行生存率的计算,Log-rank进行单因素分析,用COX回归行多因素分析。结果单纯放疗组的3、5年总生存率(OS)为92.5%、82%。单纯放疗组首程治疗后的3、5年局部控制率(LC)为82.5%、70%。Cox多因素回归分析显示分期(P=0.032)、鳞癌类型(P=0.025)、年龄(P=0.02)是影响喉癌5年生存率的独立因素。年龄>60岁、治疗前KPS评分<80、T2N0M0喉癌、低分化鳞癌及声门下型喉癌是影响OS的不良预后因素。结论单纯放疗可以作为治疗早期喉癌的首选方法。影响生存率的主要因素为:年龄、治疗前KPS评分、喉癌分期、鳞癌类型及喉癌的分型。Objective To analyze the treatment results of radiotherapy alone for patients with early stage laryngeal squamous cell cancer（T1-T2N0M0） and the prognostic factors.Methods From Jun.2003 to Dec.2008,85 patients with T1-T2N0M0 squamous cell carcinoma of the glottis were treated by radiotherapy alone.Calculating survival rate by K-M,the Log-rank was used for univariate analysis,COX model was used for multivariate analysis.Results The 3 and 5 years overall survival rates（OS） for radiotherapy group（RT group） were 92.5%,82%.The 3 and 5 years local control rate（LC） were 82.5%,70%.Multivariate analysis revealed Multivariate analysis showed that age（P=0.02）,stage（P=0.032） and the category of squamous cell carcinoma were adverse prognostic factors for OS.Univariate analysis showed： KPS score,age,stage,the category of squamous cell carcinoma and category were an important factor affecting the 5-years survival rate.Conclusions Radiotherapy alone can be the first treatment for patients with early stage laryngeal squamous cell cancer（T1-T2N0M0）.KPS score,age,stage,the category of squamous cell carcinoma and category are the independent adverse prognostic factors for early stage laryngeal squamous cell cancer.

关 键 词：早期喉癌 单纯放射治疗 预后因素 

分 类 号：R739.65[医药卫生—肿瘤]