结肠癌患者血清MCP-1含量的检测及其意义  

Clinical significance of serum monocyte chemoattractant protein-1 level in colon cancer patients

作　　者：孙力超[1] 李树婷[2] 孙立新[1] 遇珑[1] 韩璐璐[1] 刘彤[1] 杨治华[1] 冉宇靓[1] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤研究所分子肿瘤学国家重点实验室,北京100021 [2]中国医学科学院肿瘤医院内科,北京100021

出　　处：《中国卫生检验杂志》2011年第3期661-663,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家重点基础研究发展计划(973)资助项目(2009CB521804)~~

摘　　要：目的:研究结肠癌患者外周血中单核细胞趋化蛋白1(MCP-1)水平的变化,探讨其临床意义。方法:采用酶联免疫吸附法(ELISA)分别测定98例结肠癌患者(37例未发生肝转移\61例发生肝转移)和40例正常人(对照组)血清MCP-1的水平,并进行比较。结果:发生肝转移结肠癌患者血清MCP-1水平为(158.7±267.4)pg/ml,未发生肝转移结肠癌患者血清MCP-1水平为(78.3±116.1)pg/ml,正常对照组血清MCP-1水平为(57.1±48.8)pg/ml。临床相关性发现血清MCP-1水平与肝转移、临床分期相关。结论:MCP-1在结肠癌肝转移中起重要作用,监测血清MCP-1水平可反映结肠癌的进展程度,具有重要的临床价值。Objective：To study the level of monocyte chemoattractant protein 1（MCP-1） in peripheral blood in colon cancer patients with or without liver metastasis and normal people and to explore its clinical significance.Methods：Using enzyme-linked immunosorbent assay were measured in 98 cases of colon cancer patients（37 colon cancer patients without liver metastasis/61 ones with liver metastasis） and 40 healthy people（control group） serum levels of MCP-1,and compared.Results：The serum level of MCP-1 in colon cancer with liver metastasis was（158.7±267.4） pg/ml and the serum level of MCP-1 in colon cancer without liver metastasis was（78.3±116.1） pg/ml,which were significantly higher than the control group（57.1±48.8） pg/ml.The serum level of MCP-1 significantly correlated with liver metastasis and TNM stage.Conclusion：MCP-1 might plays important roles in colon cancer liver metastasis and monitor the serum MCP-1 level may reflect the degree of progress of colon cancer has important clinical value.

关 键 词：结肠癌 单核细胞趋化因子-1 

分 类 号：R735.35[医药卫生—肿瘤]