甲基黄酮醇胺对大鼠脑血栓形成模型血小板聚集及血浆TXA_2和6-keto-PGF_(1α)水平的影响  

Effect of Methylflavonolamine on Platelet Aggregation and Plasma Levels of TXA 2 and 6 keto PGF 1α in Rat Model of Cerebral Thrombosis

作　　者：杜文民[1,2,3] 王永铭[1,2,3] 汤允昭 王庸晋[1,2,3] 

机构地区：[1]上海医科大学药学院药理学教研室 [2]山西医科大学药理学教研室 [3]长治医学院药理学教研室

出　　处：《上海医科大学学报》1999年第4期271-274,共4页Journal of Fudan University(Medical Science)

摘　　要：目的研究甲基黄酮醇胺抗血小板作用的机制。方法以大鼠脑血栓形成为模型，观察甲基黄酮醇胺对大鼠脑血栓形成术２４ｈ后血小板聚集、血浆ＴＸＡ２和６ｋｅｔｏＰＧＦ１α水平的影响，以及脑电图、脑重量和病理组织学改变。结果复合血栓诱导剂１ｍｌ／ｋｇ，经颈内动脉注射能诱发大鼠同侧大脑半球内血栓形成，甲基黄酮醇胺１０～２０ｍｇ／ｋｇ能对抗大鼠脑血栓形成，降低体内血小板自发性聚集，抑制血浆ＴＸＡ２的升高。结论甲基黄酮醇胺可能通过其抗血小板聚集及影响花生四烯酸代谢而发挥抗血栓作用。Purpose To study the mechanism that methylflavonolamine(MFA) inhibited platelet function. Methods Using the rat model of cerebral thrombosis,the effects of methylflavonolamine (MFA) on platelet aggregation,plasma levels of the thromboxane B 2(TXB 2) and 6 prostaglandin F 1α (6 keto PGF 1α ),EEG,cerebral weight and pathological changes 24 h after cerebral thrombosis were investigated. Results The results showed that injected compound thrombosis inducer into arteria carotis interna induced cerebral thrombosis in the same side hemisphere,injecting MFA inhibited cerebral thrombosis,decreased platelet aggregation in vivo and plasma level of TXB 2. Conclusions The results suggest that MFA inhibits cerebral thrombosis probably by anti platelet aggregation and affecting arachidonic acids(AA) metabolism.

关 键 词：甲基黄酮醇胺 血小板聚集 血栓素 脑血栓 

分 类 号：R743.32[医药卫生—神经病学与精神病学]