石菖蒲挥发油β-环糊精包合物的制备  

The preparation technology of Acorus tatarinowii Schott oil-β-cyclodextrin inclusion complex

作　　者：王晓丽[1,2] 黄海涛[1] 蔡德富[1] 杨德柱[1] 卢长方[1] 李志勇 吴迪 李晓明[1,4] 

机构地区：[1]齐齐哈尔医学院,161006 [2]长春中医药大学 [3]黑龙江省齐齐哈尔市中医院 [4]吉林大学药学院

出　　处：《齐齐哈尔医学院学报》2011年第2期169-169,172,共2页Journal of Qiqihar Medical University

基　　金：2010年黑龙江省卫生厅项目(2009-469);2010年黑龙江省教育厅面上硕目(11551552);国家自然科学基金面上项目(30873396)

摘　　要：目的优选石菖蒲挥发油β-环糊精包合物的最佳制备条件。方法以挥发油包合率为评价指标,比较研磨法、饱和水溶液法、超声法,优选最佳制备工艺,并用薄层层析法对包合前后的挥发油性质进行分析。结果最佳的制备方法为饱和水溶液法,包合时间为2 h,温度为60℃,β-环糊精与石菖蒲挥发油的比例为8∶1。结论按优选的方法,石菖蒲挥发油可与β-环糊精形成稳定的包合物,且挥发油的利用率比较高。Objective To find the best condition of the preparation technology of Acorus tatarinowii Schott oil-β-cyclodextrin inclusion complex. Methods The grinding method was compared with the saturated water solution method and hypersound method by appraising the inclusion ratio of volatile oil.The quality of inclusion compound of volatile oil before and after being included was analyzed by TLC.Results The best method was the saturated water solution method,and the best condition was： oil： β-cyclodextrin=8：1,stirring for 2 hours at 60℃.Conclusions The complex prepared on the condition aforementioned is stable and stirring has a highest inclusion rate.

关 键 词：石菖蒲 挥发油 Β-环糊精 包合物 

分 类 号：R943[医药卫生—药剂学]