肝细胞癌组织中血管生成素样蛋白3和MAPK蛋白的表达  

Expression of ANGPTL3 and MAPK protein in hepatocellular carcinoma tissue

作　　者：李德宇[1] 陈孝平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝胆外科,武汉430022

出　　处：《郑州大学学报（医学版）》2011年第2期192-194,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省基础与前沿技术研究计划基金资助项目102300410057

摘　　要：目的:研究血管生成素样蛋白3(ANGPTL3)和有丝分裂原激活蛋白激酶(MAPK)在肝细胞癌(HCC)组织中的表达。方法:应用SP免疫组化方法检测60例HCC及其相应癌旁组织中ANGPTL3和MAPK的表达。结果:HCC组织中ANGPTL3和MAPK的阳性表达率分别为61.7%(37/60)和68.3%(41/60),癌旁组织中ANGPTL3和MAPK的阳性表达率分别为26.7(16/60)和28.3%(17/60),2者在HCC组织中的表达均高于癌旁组织(χ2分别为16.000和18.892,P均<0.001);HCC组织中两者的表达有关联(rP=0.540,P<0.001)。结论:ANGPTL3和MAPK在HCC的发生中发挥重要作用。Aim：To investigate the expressions of ANGPTL3 and MAPK in hepatocellular carcinoma（HCC） tissue.Methods：The expressions of ANGPTL3 and MAPK in 60 samples of HCC and the corresponding para-carcinoma normal tissues were detected by SP method.Results：The positive rates of ANGPTL3 and MAPK in HCC tissue were 61.7%（37/60） and 68.3%（41/60）,respectively.Those in the normal tissue were 26.7%（16/60） and 28.3%（17/60）.The expressions of ANGPTL3 and MAPK in HCC tissue were higher than those in the normol tissue（χ2 was 16.000,18.892,P0.001）.The MAPK expreesion was associated with ANGPTL3 in HCC tissue（rP=0.540,P0.001）.Conclusion：ANGPTL3 and MAPK were associated with HCC.

关 键 词：肝细胞癌 血管生成素样蛋白3 有丝分裂原激活蛋白激酶 

分 类 号：R735.2[医药卫生—肿瘤]