非小细胞肺癌预后影响因素分析  

Analysis of prognostic factors for non-small cell lung cancer

作　　者：葛辰蕾[1] 李醒亚[2] 尚可[2] 刘俊启[3] 申淑景[3] 

机构地区：[1]郑州大学基础医学院放射医学教研室,郑州450001 [2]郑州大学第一附属医院肿瘤科,郑州450052 [3]郑州大学第一附属医院放疗科,郑州450052

出　　处：《郑州大学学报（医学版）》2011年第2期216-219,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金资助项目30672423

摘　　要：目的:分析非小细胞肺癌患者预后的影响因素。方法:回顾性分析182例非小细胞肺癌患者的资料,随访并分析手术、化疗、放疗、血小板计数、γ-谷氨酰转肽酶水平、血红蛋白水平以及白细胞计数等对肺癌预后的影响,采用Kaplan-Meier法进行生存分析,采用Log-rank检验比较生存期的差异,用COX比例风险模型进行预后影响因素分析。结果:是否手术、γ-谷氨酰转肽酶水平、血红蛋白水平及白细胞计数影响患者的生存期(χ2=22.081、16.584、5.956和5.921,P均<0.05)。COX回归分析提示手术治疗、γ-谷氨酰转肽酶水平及血红蛋白水平是患者预后的独立影响因素(RR=0.381、1.883和2.010,95%CI为0.251～0.581、1.173～3.022和1.285～3.144)。结论:是否手术治疗、γ-谷氨酰转肽酶水平、血红蛋白水平及白细胞计数是影响非小细胞肺癌患者预后的主要因素。Aim：To analyze the prognostic factors for non-small cell lung cancer.Methods：A total of 182 patients with non-small cell lung cancer were enrolled.The influence of operation,chemotherapy,radiotherapy,platelet count,the level of gamma-glutamyltranspetidase,hemoglobin level and white blood cell count on the prognosis of patients was ana lyzed.Survival analysis was evaluated through Kaplan-Meier and Log-rank tests,and multivariate analysis was preformed using COX proportional hazards regression model.Results：Operation,the level of gamma-glutamyltranspetidase,hemoglobin level and white blood cell count could affect the survival of patients（χ2=22.081,16.584,5.956 and 5.921,P0.05） and COX regression model suggested that operation,the level of gamma-glutamyltranspetidase and hemoglobin level were the independent influencing factors（RR=0.381,1.883,and 2.010,95% CI 0.251~0.581,1.173~3.022,and 1.285~3.144）.Conclusion：Operation,the level of gamma-glutamyltranspetidase,hemoglobin level and white blood cell count could affect the prognosis of patients with non-small cell lung cancer.

关 键 词：非小细胞肺癌 预后 多因素分析 

分 类 号：R734.2[医药卫生—肿瘤]