克拉瑞啶与川芎嗪对照治疗急性缺血性脑卒中60例  

STUDY ON THE EFFICACY OF CLARANTIN COMPARISON WITH LIGUSTRAZINE IN TREATMENT OF 60 CASES OF ACUTE ISCHEMIC STROKE

作　　者：肖卫忠[1] 李美琳[1] 康德瑄[1] 

机构地区：[1]北京医科大学第三临床医学院神经科,北京100083

出　　处：《中国新药杂志》1999年第10期684-685,共2页Chinese Journal of New Drugs

摘　　要：目的 :探讨克拉瑞啶治疗缺血性脑卒中的临床效果。方法 :选择经临床、头颅CT和 /或MRI确诊的 60例急性缺血性脑卒中患者 ,随机分为 2组。治疗组与对照组分别给予克拉瑞啶 160mg及川芎嗪 12 0mg ,均加入5 0 0ml低分子右旋糖酐中静点 ,qd ,连用 2周。 结果 :治疗组患者用药后神经功能缺损评分减少及总的生活能力有明显提高 (P <0 .0 0 1) ;血小板聚集率及血浆粘度有明显下降 (P <0 .0 1) ;两组患者总的疗效有明显差异 (P <0 .0 0 5 )。结论 :克拉瑞啶对急性缺血性脑卒中有较好疗效 。OBJECTIVE:To explore the efficacy of clarantin in treatment of acute ischemic stroke.METHODS:Sixty patients with acute ischemic stroke diagnosed by cranial CT and/or MRI scaning,were randomly divided to receive 160 mg clarantin or 120 mg ligastrazine once daily for 2 continuous weeks.Both agents were given by infusion after mixed with 500 ml Dextram 40.RESULTS:For active group,the dysfunction in nervous system and living ability were improved significantly ( P <0.001) and the platelet aggregation and plasma viscosity were decreased significantly ( P <0.01).There was significant difference in total theraputic effect ( P <0.005)between active and control groups.CONCLUSION:Clarantin is effective in treatment of acute ischemic stroke especially for mild to moderate patients.

关 键 词：克拉瑞啶 急性 缺血性脑卒中 治疗 疗效观察 

分 类 号：R743.305[医药卫生—神经病学与精神病学]