具有家族背景大肠癌微卫星不稳定性研究  

STUDY ON MICROSATELLITE INSTABILITY IN COLORECTAL CANCER WITH FAMIL I AL PREDISPOSITION

作　　者：吴保平[1] 张亚历[1] 张振书[1] 周殿元[1] 高春芳[2] 郭文[1] 张立力[1] 

机构地区：[1]第一军医大学南方医院,广州510515 [2]解放军第150医院

出　　处：《解放军医学杂志》1999年第5期354-357,共4页Medical Journal of Chinese People's Liberation Army

基　　金："九.五"军队医药卫生科研基金重点课题;广东省自然科学基金

摘　　要：为了解具有家族背景大肠癌微卫星不稳定性（ＭＩＮ）及其与临床病理表现的关系，应用银染聚合酶链反应－单链构相多态性（ＰＣＲ－ＳＳＣＰ）分析技术，对４６ 例大肠癌进行研究。结果：ＭＩＮ在具有家族背景大肠癌中的表达明显高于无家族史的散发性大肠癌（Ｐ＜ ０．０５）。癌家族史、ＭＩＮ 的表达与大肠癌发病年龄轻、右半大肠癌、大肠外癌及低分化癌的发生率高均有明显关系（Ｐ＜ ０．０１，Ｐ＜ ０．０５），而与多原发癌的发生及转移复发无明显关系（Ｐ＞ ０．０５）。说明ＭＩＮ在具有家族背景大肠癌中起着明显的作用。ＭＩＮ 阳性和家族背景大肠癌具有发病年龄轻、右半大肠癌。To evaluate the microsatellite instability (MIN) in colorectal cancer(CRC) with familial predisposition and its clinic pathologly connection. MIN was examined in 46 cases of CRC, using silver staining polymerase chain reaction single strand conformation polymorphism (PCR SSCP) technique. Results: The incidence of MIN positive was higher in CRC Wirth familial predisposition than sporadic CRC ( P <0.05). Familial predisposition and MIN positive related strongly with early age of cancer onset, the proclivity for proximal colon, poor differentiation and extracolorectal malignancy( P <0.01, P <0.05). It showed significant association with multiplicity and metastasis of colorectal cancer ( P >0.05). Conclusions: MIN might be an important contributor to CRC with familial predisposition. CRC with familial predisposition and MIN positive showed early age of cancer onset, proclivity for proximal colon, poor differentiation and extracolorectal malignancy.

关 键 词：结直肠肿瘤 家族背景 微卫星不稳定性 

分 类 号：R735.350.2[医药卫生—肿瘤]