动脉粥样硬化及脑梗死患者血中HCMV IgM抗体检测及临床意义  

The Detection and Clinical Significance of Serum HCMV IgM in Patients with Atherosclerosis and Cerebral Infarction

作　　者：沈雪莉[1] 张薇 张斯萌[3] 崔梦遥[3] 

机构地区：[1]中国医科大学第一临床学院神经内科,沈阳110001 [2]辽宁电力中心医院神经内科,沈阳110015 [3]中国医科大学94期临床医学七年制,沈阳110001

出　　处：《中国医科大学学报》2011年第4期346-348,共3页Journal of China Medical University

摘　　要：目的检测颈动脉粥样硬化及脑梗死患者血中人巨细胞病毒(HVMV)抗体,并探讨其临床意义。方法应用ELISA方法对采集的77例颈动脉粥样硬化患者(颈动脉粥样硬化组)及81例脑梗死患者(脑梗死组)血清进行HCMV IgM抗体检测,并与72例健康对照(正常对照组)进行比较。结果正常对照组、颈动脉粥样硬化组及脑梗死组血中HCMV IgM抗体OD值分别为(0.60±0.05)、(0.81±0.08)和(0.94±0.07),HCMV IgM抗体阳性率分别为17.8%、39.0%和49.4%。与对照组相比,颈动脉粥样硬化组和脑梗死组血中HCMVIgM抗体水平和HCMV IgM抗体阳性率均明显增高,差异有统计学意义(P<0.01)。HCMV IgM抗体阳性与颈动脉粥样硬化及脑梗死的OR值分别为2.95和4.51,95%的可信区间分别为[1.39～6.27]和[2.16～9.40]。结论颈动脉粥样硬化及脑梗死患者血中HCMV IgM抗体增高,提示HCMV感染与两者的发生相关,可能是其危险因素之一;检测HCMV抗体可以为动脉粥样硬化及脑血管事件的发生提供信息,具有一定的临床意义。Objective To determine the levels of serum HCMV antibody in patients with carotid atherosclerosis and cerebral infarction,and explore its clinical significance.Methods The levels of serum HCMV antibody in 77 patients with carotid atherosclerosis and 81 patients with cerebral infarction were determined by ELISA method and compared with 72 normal control.Results The OD values of serum HCMV antibody IgM were 0.60±0.05,0.81±0.08 and 0.94±0.07,and the positive rate of it was 17.8%,39%,49.4% in the control group,carotid atherosclerosis group and cerebral infarction group respectively.There were significantly elevations in the levels of serum HCMV antibody and its positive rates in the groups of carotid atherosclerosis and cerebral infarction than in controls（P 0.01）.The odd ratio（OR）and 95% confidence intervals（CI）between HCMV antibodies positive and carotid atherosclerosis and cerebral infarction were 2.95 [95% CI：1.39～6.27]and 4.51 [95%CI：2.16～9.40]respectively.Conclusion The levels of serum HCMV antibody IgM were higher in patients with carotid atherosclerosis and cerebral infarction,which suggested that there was a relationship between the infection of HCMV and carotid atherosclerosis and cerebral infarction.The incidence of atherosclerosis and cerebral vascular events can be forecasted when determinating HCMV antibody IgM.

关 键 词：人巨细胞病毒 动脉粥样硬化 脑梗死 

分 类 号：R743.1[医药卫生—神经病学与精神病学]