缓释氟尿嘧啶在腹腔镜直肠癌根治术中的安全性及疗效  

Safety and curative efficacy of sustained-release fluorourancil during radical laparoscopic surgery of rectal carcinoma:Clinical observations

作　　者：李松岩[1] 陈凛[1] 宁宁[1] 许声江[1] 李荣[1] 杜晓辉[1] 

机构地区：[1]解放军总医院普通外科,北京100853

出　　处：《军医进修学院学报》2011年第5期423-425,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：军队"十一五"科技攻关项目(06G107);北京市科技新星计划课题(2006A51)~~

摘　　要：目的探讨腹腔镜下植入缓释氟尿嘧啶治疗直肠癌的安全性及疗效。方法回顾性分析2006年3月-2009年1月我院普通外科172例行腹腔镜辅助下直肠癌根治术患者,观察组90例,术中在腹腔镜下将缓释氟尿嘧啶撒布在盆腔的瘤床周围及肝脏表面进行区域化疗;对照组82例,未行区域化疗。结果两组患者术前、术后及组间肝、肾功能和白细胞比较差异无统计学意义(P>0.05)。观察组术后1年、2年局部复发率分别为1.11%(1/90)、7.78%(7/90),对照组分别为8.54%(7/82)、17.07%(14/82),1年局部复发率两组比较差异有统计学意义(P<0.05)。观察组术后1年、2年肝转移率分别为5.55%(5/90)、17.78%(16/90),对照组分别为15.85%(13/82)、26.83%(22/82),1年肝转移率两组比较差异有统计学意义(P<0.05)。结论缓释氟尿嘧啶在腹腔镜下直肠癌根治术中进行区域性化疗安全有效,是减少直肠癌局部复发及肝脏转移的有效方法。Objective To study the safety and curative effect of sustained-release fluorourancil during laparoscopic rectal carcinoma surgery.Methods One hundred and seventy-two patients with rectal carcinoma who underwent laparoscopic radical surgery in our department from March 2006 to January 2009 were divided into observation group（n=90） and control group（n=82）.Patients in observation group received regional chemotherapy with sustained-release fluorourancil under laparoscope.Patients in control group did not receive regional chemotherapy with sustained-release fluorourancil under laparoscope.Their outcomes were retrospectively analyzed.Results No difference was found in liver and kidney functions and white blood cell count between the two groups before and after operation（P0.05）.The local recurrence rate of rectal carcinoma was 1.11%（1/90） and 7.78%（7/90） respectively in observation group,and 8.54%（7/82） and 17.07%（14/82） respectively in control group 1 and 2 years after operation（P0.05）.The liver metastasis rate was 5.55%（5/90） and 17.78%（16/90） respectively in observation group,and 15.85%（13/82） and 26.83%（22/82） respectively in control group 1 and 2 years after operation（P0.05）.Conclusion Sustained-release fluorourancil is effective and safe as a regional chemotherapy agent for rectal carcinoma during laparoscopic radical surgery,and can reduce its local recurrence and liver metastasis.

关 键 词：腹腔镜 直肠癌 缓释化疗 

分 类 号：R735[医药卫生—肿瘤]