Ⅰ型IFN的结构、信号传导和功能  

Structure,function and signal transduction of IFN type Ⅰ

作　　者：孙琳[1] 毕惠娟[2] 王健[2] 

机构地区：[1]安徽理工大学医学院妇产科护理学教研室,安徽淮南232001 [2]安徽理工大学医学院病原学与免疫学教研室,安徽淮南232001

出　　处：《中国微生态学杂志》2011年第4期375-380,383,共7页Chinese Journal of Microecology

基　　金：安徽省自然科学基金(090413138);安徽省教育厅自然基金重点项目(KJ2010A086;KJ2009A032;KJ2007A019)

摘　　要：IFN是一种具有广谱抗病毒、抗肿瘤、抑制细胞增殖及免疫调节作用的活性蛋白,至少可分为α、β、δ、ε、κ、ω、τ和limitin八种,分子质量约为18.5 kDa,包括4个保守的半胱氨酸,形成2对分子内二硫键。IFN-α/βR是IFN-α和IFN-β共同结合受体,包括IFNAR1和IFNAR2,IFNAR1仅有1个亚单位,IFNAR2由3个亚单位组成。IFN与位于细胞膜上的特异性受体结合,主要经JAK-STAT途径介导信号传导,不仅能通过PKR、2-′5′OAS、Mx和ADAR1等途径发挥抗病毒作用,还能通过对淋巴细胞和巨噬细胞的调节以及诱导MHC分子表达等途径发挥直接或间接的免疫调节作用。IFN,a kind of broad-spectrum anti-viral active protein of 18.5 kDa,including four conserved cysteines which froms two pairs of intramolecular disulfide bonds,can be divided into at least 8 types α,β,δ,ε,κ,ω,τ and limitin.It has better effects of anti-tumor,inhibition of cell proliferation and immune regulation.IFN-α/β receptor,the co-receptor binding to IFN-α and IFN-β,includes IFNAR1 and IFNAR2.IFNAR1 has only one subunit,while IFNAR2 is composed of three sub-units.As IFN combines with its specific receptors on the cell membrane,the main pathway of JAK-STAT signal transduction can be activated.On the basis of above pathway,the antiviral effects of IFN can be demonstrated through multiple ways,such as PKR,2＇-5＇OAS,Mx,and ADAR1.The direct or indirect immune regulatory roles of IFN can be played via the regulation of lymphocytes and macrophages and the expression of MHC molecules.

关 键 词：IFN 信号转导 结构 功能 

分 类 号：R513.2[医药卫生—内科学]