急性心肌梗死与血尿酸水平关系研究  

STUDY OF THE RELATIONSHIP BETWEEN SERUM URIC ACID AND ACUTE MYOCARDIAL INFARCTION

作　　者：熊富权[1] 

机构地区：[1]内江市第一人民医院心内科,四川内江641000

出　　处：《泸州医学院学报》2011年第2期145-149,共5页Journal of Luzhou Medical College

摘　　要：目的:通过观察急性ST段抬高型心肌梗死(STEMI)不同梗死范围患者血尿酸(SUA)水平的变化,探讨急性心肌梗死与血尿酸水平的关系。方法:选择急性ST段抬高型心肌梗死(STEMI)患者62例,只有1个梗死部位者为单壁组,30例;≧2个梗死部位者为多壁组,32例。所有患者均于发病12小时内入院,并于6小时内行急诊冠状动脉造影及经皮冠状动脉介入治疗(PCI)。行血尿酸、心肌酶谱、血脂及心脏超声检查,随访30天。对两组急性心肌梗死患者血尿酸(SUA)值与磷酸肌酸激酶同工酶(CK-MB)值、心功能、随访期间心血管事件发生率进行对比分析。结果:单壁组和多壁组血尿酸值分别为(319.96±106.62μmol/L)VS(388.99±81.20μmol/L),CK-MB值为(39.38±20.18U/L)VS(111.06±48.60U/L),左室舒张末期内径(LVDD)为(48±4mm)VS(53±6mm),左室射血分数(LVEF)为(60±5%)VS(42±8%),两组比较,差异有统计学意义(P<0.05),且血尿酸与CK-MB呈正相关(r=0.319,P<0.05),与左室射血分数呈负相关(r=-0.284,P<0.05);单壁组和多壁组心律失常发生率分别为16.67%和40.62%,梗死后心绞痛为3.33%和9.37%,充血性心力衰竭为13.33%和34.37%,心血管死亡为3.33%和18.75%,两组比较,差异有统计学意义(P<0.05)。结论:急性心肌梗死合并高水平血尿酸患者梗死面积较大,心功能差,近期心血管事件发生率高。Objective：To investigate the relationship of serum uric acid and ST elevated acute myocardial infarction（STEMI）.Methods：62 patients with STEMI were divideal into single-wall group（30 patients）and multi-wall group（32 patients）according to the distribution of infarction.All patients were admitted within 12 hours and were made emergency coronary angiography and PCI.Uric acid,CK-MB,lipids and echocardiography were inspected.All patients were followed up for 30 days.The uric acid cardiac function and cardiovascular events were analyzed in the two groups.Results：Compared with the single-wall group,the level of uric acid and CK-MB were higher in the multi-wall group（P0.05）,and there was poor cardiac function and more cardiovascular events（P0.05）.Conclusions：The patients of Acute myocardial infarction with high uric acid have large infarct size、poor cardiac function and more Cardiovascular events.

关 键 词：急性ST段抬高性心肌梗死 血尿酸 心功能 心血管事件 

分 类 号：R734.2[医药卫生—肿瘤]