JWAG723T多态性与食管癌易感性  

The relationship between JWA G723T polymorphism and the risk of esophageal cancer

作　　者：王卓[1] 高长明[1] 丁建华[1] 吴建中[1] 张晓梅[1] 张元颖[1] 李苏平[1] 刘燕婷[1] 曹海霞[1] 

机构地区：[1]江苏省肿瘤防治研究所流行病研究室,江苏南京210009

出　　处：《中国肿瘤外科杂志》2011年第2期96-98,共3页Chinese Journal of Surgical Oncology

基　　金：江苏省肿瘤防治研究所青年基金(ZQ200404)

摘　　要：目的 探讨JWA G723T多态性与食管癌易感性之间的关系.方法 采用多聚酶链反应（polymerase chain reaction,PCR）和变性高效液相色谱法（denaturing high performance liquid chromatography,DHPLC）检测93例食管癌患者和200例对照者JWA基因G723T多态性并进行分析.结果 病例组和对照组JWA G723T基因分布频度有显著差异（χ2=15.556,P=0.001）.与T/T基因型相比,T/G基因型发生食管癌的性别、年龄调整比值比上升到1.50 （95%CI：1.14～1.95）,G/G基因型发生食管癌的性别、年龄调整比值比上升到4.53 （95%CI：1.62～12.65）.合并T/G和G/G基因型分析显示G等位基因发生食管癌的性别、年龄调整比值比上升到2.50 （95%CI：1.50～4.16）,显著增加食管癌的易感性（P〈0.01）.结论 JWA G723T多态性与食管癌易感性相关.Objective To investigate the association between of JWA G723T polymorphisms and the risk of esophageal cancer. Methods We conducted a case-control study of 93 cases of esophageal cancer and population-based 200 controls in Jiangsu province, China. JWA G723T genotypes were identified by PCR and denaturing high performance liquid chromatography （DHPLC）. Logistic regression was used to calculated odds ratios （OR） and 95% confidence intervals （95% CI）. Results The frequencies of JWA G723T show significant difference between cases and controls（χ^2 = 15. 556 ,P = 0.001 ）. Relative to JWA 723 T/T genotype, the age and sex adjusted OR for T/G was 1.50 （95 % CI ： 1.14 - 1.95 ）, the adjusted OR for G/G was 4.53 （95% CI： 1.62 -12.65） ,and the adjusted OR for G allele was 2.50 （95%CI： 1.50 -4.16）. The JWA G723T G allele showed moderately increased risk for esophageal cancer （ P 〈 0.01 ）. Conclusions There was a significant association between the JWA G723T polymorphisms and esophageal cancer susceptibility.

关 键 词：食管癌易感性 JWA G723T多态性 病例对照研究 

分 类 号：R735.1[医药卫生—肿瘤]