对ASCUS患者HPV-DNA检验结果的分析  

An analysis of detection results of HPV-DNA to diagnoze patients with ASCUS

作　　者：周桂华[1] 谭浩[1] 

机构地区：[1]湖南省妇幼保健院,湖南长沙410008

出　　处：《中国妇幼健康研究》2011年第2期210-211,共2页Chinese Journal of Woman and Child Health Research

摘　　要：目的通过HPV-DNA检测分析宫颈液基细胞学检查结果为未明确意义的不典型鳞状细胞（ASCUS）患者的临床分流管理，为临床治疗方法的选择提供依据。方法应用杂交捕获法（HC2）对891例经宫颈液基细胞学检查结果为ASCUS患者进行HPV—DNA检测（包括13种高危型和5种低危型）。结果891例患者检测结果阳性者566例，占63．5％；其中高危型HPV—DNA阳性者190例，占21．3％，低危型HPV—DNA阳性者376例，占42．2％；阴性者325例，占36．5％。结论有针对性地进行活组织病理检查可有效地指导临床选择治疗方法，其为诊断宫颈癌及癌前病变的重要手段，与宫颈细胞学检查相结合可提高宫颈病变的检出率。Objective To determine whether patients who were diagnozed as atypical squamous cell of undetermined significance（ASCUS） by cervical thin prep cytology test （TCT） were high-risk population of precancerous lesions or cervical cancer according to their HPV （human papillomavirus ）-DNA detection results, so as to provide evidence for clinical treatment choice and patient classified administration. Methods The hybrid capture （HC2） method was used to detect HPV-DNA of 891 patients who were diagnozed as ASCUS by TCT, including 13 high-risk and 5 low-risk types of HPV. Results Among 891 patients with ASCUS, HPV-DNA of 566 patients was positive and the positive rate of HPV-DNA was 63.5%. Of which, 190 patients had positive high-risk types of HPV-DNA （21.3%）~, 376 patients had positive low-risk types of HPV-DNA （42.2%） and 325 patients had negative HPV-DNA （36.5%）. Conclusion HPV-DNA detection by using HC2 method is an important diagnostic method for those patients with high risk factors of cervical cancer and precancerous lesions and effectively guide clinical treatment of the patients. The detectable rate of cervical lesions can be improved if the detection is combined with cervical cytological examination.

关 键 词：宫颈液基细胞学 人乳头瘤病毒 宫颈癌 宫颈上皮内瘤变 

分 类 号：R737.3[医药卫生—肿瘤]