荧光图像早期癌症诊断仪对消化道肿瘤的研究  

Study of Clinical Application on Autofluorescence Imaging in the Diagnosis of digestive tract cancer

作　　者：叶衍铭 萧树东[2] 戈之诤[2] 郑家骠 夏敬芳 姜智敏[2] 项大荣 

机构地区：[1]上海盛莹光电科技有限公司,上海200233 [2]上海交通大学医学院附属仁济医院消化内科,上海市消化疾病研究所,上海200001

出　　处：《世界肿瘤杂志》2010年第2期86-88,100,F0003,共5页Tumour Journal of the World

摘　　要：目的探讨自体荧光内镜对消化道肿瘤诊断的临床意义。方法采用以自体荧光为技术基础的荧光内镜检查消化道肿瘤，以病理检查结果为标准分析其诊断准确性。结果自体荧光内镜对早期癌的检出率为86．7％，对进展期癌的检出率为95．5％；其诊断消化道恶性肿瘤的总体敏感性、特异性、阳性预测值、阴性预测值和诊断准确率分别为94．2％、94．0％、93.3％、94．8％和94．1％。结论自体荧光内镜对消化道恶性肿瘤的诊断具有高敏感性，对检出形态特征不明显的病变较普通内镜有更大优势，易于发现肉眼难以识别的可疑病灶并确定其发生部位和范围，可精确指导活检，对提高早期癌的检出率具有重要意义，并有很高的应用价值。Objective To further explore the clinical significance of autofluorescence endoscopy in the diagnosis of digestive tract cancer. Methods The newly developed autofluorescence endoscopy was used to detect the digestive tract cancer, the accuracy was analyzed according to the results of pathological examination. Results The detection rate of autofluorescence endoscopy for early cancer was 86.7%, and for advanced cancer was 95.5%. Its overall sensitivity, specificity, positive predictive value and negative predictive value were 94.2%, 94.0%, 93.3% and 94.8%, respectively. The diagnostic accuracy was 94.1% Conclusions Autofluorescence endoscopy is sensitive for the detection of gastrointestinal malignancies. It is advantageous over conventional endoscopy in detecting atypical and suspicious lesions, in determining the site and extent of lesions, and in guiding biopsy more precisely. Autofluorescence endoscopy may become a potential tool for the early detection of malignancies.and it has very high value in clinical application.

关 键 词：消化道肿瘤 自体荧光 荧光图像 早期癌症诊断 

分 类 号：R735[医药卫生—肿瘤]