还原型谷胱甘肽防治奥沙利铂神经毒性30例临床观察  

Clinical observation of reduced glutathione in preventing the peripheral neurotoxicity of oxaliplatin in 30cases of patients

作　　者：张为强 董小芳 蔡巧英 

机构地区：[1]浙江省东阳市人民医院,浙江东阳322100

出　　处：《世界肿瘤杂志》2010年第2期113-114,共2页Tumour Journal of the World

摘　　要：目的观察还原型谷胱甘肽防治含奥沙利铂（L-OHP）方案联合化疗引起的外周神经毒性的疗效。方法60例接受含奥沙利铂（L-OHP）方案联合化疗的结直肠癌患者分为两组，试验组30例，对照组30例，试验组化疗的前1d开始给予还原型谷胱甘肽1．2g静脉滴注，连用5-7d；对照组单用化疗；两组化疗方案、给药方法相同，共用药6个周期。结果试验组患者外周神经毒性发生率26．67％（8／30），明显低于对照组的60．0％（18／30），P〈0．01。结论还原型谷胱甘肽对L-OHP的神经毒性有明显的预防和治疗作用。Objective To observe the efficacy of reduced glutathione in preventing the peripheral neurotoxicity of oxaliplatin. Methods 60 cases with colorectal cancer treated with L-OHP／5Fu regimen chemotherapy were randomly divided into prevention group （n=30） and control group （n=30）. One day before chemotherapy with oxaliplatin, the prevention group cases received infusion of 1.2 g/m2 of reduced glutathione intravenously. Control group only received chemotherapy treatment. Results The rates of neurotoxicity of the prevention group and control group were respectively 26.67% （8/30） and 60.0% （18/30）, （P〈0.01）. Conclusions It displays the efficacy of reduced glutathione in preventing the peripheral neurotoxicity of oxaliplatin.

关 键 词：还原型谷胱甘肽 奥沙利铂 神经毒性 

分 类 号：R735.3[医药卫生—肿瘤]