HBV相关性肾炎与HBVCP区基因变异的相关性研究  

The relative investigation of hepatitis B virus in the core promoter regions gene mutations and hepatitis B virus-associated glomerulonephritis

作　　者：崔晓影[1] 安惠霞[1] 李霜青[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院肾内科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2010年第6期553-555,共3页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(080620)

摘　　要：目的探讨乙型肝炎病毒相关性肾炎(hepatitis B virus-associated glomerulonephritis,HBV-GN)易感性与乙型肝炎病毒(HBV)CP区基因变异的关系。方法选择19例HBV-GN为实验组,22例慢性HBV感染者为对照组,应用基因测序技术检测HBV血浆CP区基因位点的变异。结果 CP区中nt1727和nt1773位点HBV-GN组的变异率显著高于HBV组(100%和59.1%,47.4%和13.6%,P<0.05)。nt1762/1764联合变异率在两组中的差别无统计学意义(P>0.05)。结论 HBV-GN易感性可能与HBV的CP区基因变异有关。Objective To study the correlation of hepatitis B virus（HBV） in the core promoter regions gene mutations in patients with hepatitis B virus associated glomerulonephritis（HBV-GN）.Methods Nineteen patients of HBV-GN were chosen as experimental group and 22 patients of chronic hepatitis B（CHB） as control group.Gene mutations of HBV were detected by complete genome sequences technique in the core promoter/precore regions.Results In the core promoter regions,the prevalence of the nt1727 and nt1773 mutations patients were significantly higher in the HBV-GN group than in the CHB group（100%vs 59.1%,and 47.4%vs 13.6%,P0.05）.The prevalence of the nt1762/1764 mutation was not significantly different between the HBV-GN group and the CHB group（P0.05）.Conclusion There maybe relationships between HBV in the core promoter regions gene mutations and HBV-GN.

关 键 词：乙型肝炎病毒 乙型肝炎相关性肾炎 基因变异 

分 类 号：R512.62[医药卫生—内科学] R692.3[医药卫生—临床医学]