卵巢癌危险因素的Meta分析  

Meta-analysis of case-control trials on risk factors of ovarian neoplasm

作　　者：冯丹[1] 刘佳丽[1] 许崇安[1] 

机构地区：[1]中国医科大学附属第四医院肿瘤内科,辽宁沈阳110032

出　　处：《中华肿瘤防治杂志》2010年第22期1805-1807,1827,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨卵巢癌发病的可能危险因素及致病机制。方法:计算机检索CBMdisc、CNKI、维普及万方电子数据库,手工检索相关杂志。由2位评价者独立检索和提取资料并交叉核对,纳入研究卵巢癌危险因素的相关病例对照试验。Meta分析软件是Cochrane协作网提供的RevMan5.0。结果:共纳入病例对照试验9个,包括3 169例患者,其中病例组1 320例,对照组1849例。Meta分析结果显示,初潮年龄、初产年龄、痛经史、不孕史、恶性肿瘤家族史、大便不规律史及负性生活事件是卵巢癌发病的危险因素;足月妊娠史、多孕史、多产史、哺乳史、多次流产史、多次结婚史、避孕药服用史及宫内节育史是卵巢癌发病的保护性因素。结论:卵巢癌主要危险因素包括初潮年龄、初产年龄、痛经史、不孕史、恶性肿瘤家族史、大便不规律史及负性生活事件,足月妊娠史、多孕史、多产史、哺乳史、多次流产史、多次结婚史、避孕药服用史及宫内节育史是卵巢癌发病的保护性因素。OBJECTIVE：To investigate potential risk factors of ovarian neoplasm and their pathogenic mechanism.METHODS：Search the CBMDISC,CNKI,VIP and Wanfang database by computer retrieval.Relevant journals,conference papers,thesis and reference list for clinical controlled trials on risk factors of ovarian cancer were also searched by manual retrieval.Two reviewers independently assessed trial quality and extracted data.The Cochrane Collaboration＇s software RevMan 5.0 was used for meta-analysis.RESULTS：Nine studies involving 3 169 patients were identified,including 1 320 cases in case group and 1 849 cases in control group.The results of meta-analysis showed that：menarche age,first delivery age,dysmenorrhea history,infertility history,family history of cancer,bowel irregularity history and negative life events were the risk factors of ovarian cancer.However,full-term pregnancy,multiple pregnancy history,prolific history,lactation history,repeated abortions history,multiple marriages history,contraceptive taking history and intrauterine history were the protective factors of ovarian cancer.CONCLUSIONS：The main risk factors of ovarian cancer include menarche age,first delivery age,dysmenorrhea history,infertility history,family history of cancer,bowel irregularity history and negative life events.However,full-term pregnancy,multiple pregnancy history,prolific history,lactation history,repeated abortions history,multiple marriages history,contraceptive taking history and intrauterine history are the protective factors of ovarian cancer.

关 键 词：卵巢肿瘤 危险因素 病例对照试验 META分析 

分 类 号：R737.31[医药卫生—肿瘤]